USP39 - ubiquitin specific peptidase 39 Gene

Also Known as 65K; SAD1; CGI-21; HSPC332; SNRNP65

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10713

About USP39

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,602,861-85,649,283 (from NCBI)

This gene has 20 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 14.6), placenta (RPKM 13.8) and 25 other tissues.

Summary

Predicted to enable thiol-dependent Deubiquitinase and zinc ion binding activity. Involved in spliceosomal complex assembly. Located in nucleoplasm. Part of U4/U6 x U5 tri-snRNP complex. [provided by Alliance of Genome Resources, Apr 2022]

USP39 Products (5)

mRNA Protein Name
NM_001256725.2 NP_001243654.1 U4/U6.U5 tri-snRNP-associated protein 2 isoform 1
NM_001256726.2 NP_001243655.1 U4/U6.U5 tri-snRNP-associated protein 2 isoform 2
NM_001256727.2 NP_001243656.1 U4/U6.U5 tri-snRNP-associated protein 2 isoform 3
NM_001256728.2 NP_001243657.1 U4/U6.U5 tri-snRNP-associated protein 2 isoform 4
NM_006590.4 NP_006581.2 U4/U6.U5 tri-snRNP-associated protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
NOT enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
18728397 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23602568 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
11350945 GOA
involved in spliceosomal complex assembly IMP
IMP: Inferred from mutant phenotype
11350945 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of U4/U6 x U5 tri-snRNP complex IDA
IDA: Inferred from direct assay
11350945 GOA
part of U4/U6 x U5 tri-snRNP complex IPI
IPI: Inferred from physical interaction
30975767 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11350945 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP39 Protein Structure

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (129 - 185)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (225 - 550)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 565 a.a.
Protein Preferred Names Protein Names

U4/U6.U5 tri-snRNP-associated protein 2

  • SAD1 homolog

USP39 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
USP39 Q53GS9 LRRK2 Homo sapiens Q5S007
Protein Array
29513927
Cross: Cross-species interaction Intra: Intraspecies interaction

USP39 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P87133 USP39 Antibody (YA6826) WB, IHC-P Human, Mouse, Rat
HY-P87134 USP39 Antibody (YA6827) WB, IHC-P Human, Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-180907 PROTAC USP39 Degrader-1 98.61% Unkown
HY-170393 iBFAR2 Inhibitor 97.24% Unkown
HY-180906 (S,R,S)-AHPC-C2-PEG3-NH2 / Unkown
HY-RS15550 USP39 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19044 Usp39 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25534 Usp39 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus USP39 RGD RGD:1308103
Bos taurus USP39 VGNC VGNC:36728
Mus musculus USP39 MGD MGI:107622
Canis familiaris USP39 VGNC VGNC:48194
Macaca mulatta USP39 VGNC VGNC:79227
Felis catus USP39 VGNC VGNC:66885
Others USP39 NCBI