country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

NXT2 - nuclear transport factor 2 like export factor 2 Gene

Also Known as P15-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55916

About NXT2

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:109,535,824-109,544,698 (from NCBI)

This gene has 4 transcripts (splice variants), 218 orthologues and 2 paralogues. Broad expression in testis (RPKM 16.8), bone marrow (RPKM 5.3) and 23 other tissues.

Summary

The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]

NXT2 Products (3)

mRNA	Protein	Name
NM_001242617.2	NP_001229546.1	NTF2-related export protein 2 isoform 2
NM_001242618.2	NP_001229547.1	NTF2-related export protein 2 isoform 3
NM_018698.5	NP_061168.2	NTF2-related export protein 2 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of nuclear RNA export factor complex	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NXT2 Protein Structure

NTF2

0
100
142 a.a.

Protein Preferred Names	Protein Names
NTF2-related export protein 2	protein p15-2

NXT2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	NXT2	Q9NPJ8	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	25416956
Intra	NXT2	Q9NPJ8	HEL-S-30	Homo sapiens	V9HWB8	Y2H Array	25416956
Intra	NXT2	Q9NPJ8	PTPN3	Homo sapiens	P26045	Y2H Prey Pooling	25416956
Intra	NXT2	Q9NPJ8	SSBP3	Homo sapiens	Q9BWW4	Validated Y2H	25416956
Intra	NXT2	Q9NPJ8	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	NXT2	Q9NPJ8	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	NXT2	Q9NPJ8	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	NXT2	Q9NPJ8	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	NXT2	Q9NPJ8	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25416956
Intra	NXT2	Q9NPJ8	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	NXT2	Q9NPJ8	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	NXT2	Q9NPJ8	TRIM23	Homo sapiens	P36406	Y2H Array	25416956
Intra	NXT2	Q9NPJ8	CEP63	Homo sapiens	Q96MT8	Y2H Prey Pooling	25416956
Intra	NXT2	Q9NPJ8	CEP63	Homo sapiens	Q96MT8	Validated Y2H	25416956
Intra	NXT2	Q9NPJ8	NXF3	Homo sapiens	Q9H4D5	Y2H Array	25416956
Intra	NXT2	Q9NPJ8	NXF3	Homo sapiens	Q9H4D5	Y2H Pooling	16189514
Intra	NXT2	Q9NPJ8	NXF3	Homo sapiens	Q9H4D5	Y2H Array	31515488
Intra	NXT2	Q9NPJ8	NXF3	Homo sapiens	Q9H4D5	Validated Y2H	25416956
Intra	NXT2	Q9NPJ8	USP54	Homo sapiens	Q70EL1	Y2H Array	25416956
Intra	NXT2	Q9NPJ8	USP54	Homo sapiens	Q70EL1	Y2H Prey Pooling	25416956
Intra	NXT2	Q9NPJ8	USP54	Homo sapiens	Q70EL1	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cancerophobia	Cancer Phobia Fear Of Getting Cancer
Nosophobia
Amme Complex	Alport Syndrome, Mental Retardation, Midface Hypoplasia, And Elliptocytosis ATS-MR Alport Syndrome-Intellectual Disability-Midface Hypoplasia-Elliptocytosis Syndrome Chromosome Xq22.3 Telomeric Deletion Syndrome Amme Syndrome Alport Syndrome With Intellectual Disability, Midface Hypoplasia And Elliptocytosis
Trachea Adenoid Cystic Carcinoma	Tracheal Adenoid Cystic Carcinoma Adenoid Cystic Carcinoma Of Trachea
Congenital Myasthenic Syndrome 7	Cms7 Congenital Myasthenic Syndrome 7 Presynaptic Myasthenic Syndrome, Congenital, Type 7, Presynaptic
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS09721	NXT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NXT2	VGNC	VGNC:75430
Mus musculus	NXT2	MGD	MGI:2147914
Rattus norvegicus	NXT2	RGD	RGD:1560204
Bos taurus	NXT2	VGNC	VGNC:32385
Canis familiaris	NXT2	VGNC	VGNC:44080
Others	NXT2	NCBI