GS-1291269
GS-1291269 is a potent and neutral ketohexokinase (KHK) inhibitor, with IC50s of 0.38 and 2.1 nM against KHK-C and KHK-A, respectively. GS-1291269 demonstrates liver and kidney fructose-1-phosphate (F1P) reduction in a fructose challenge model in rats. GS-1291269 can be used for kidney disease and metabolic-dysfunction-associated steatotic liver disease (MASLD) research.
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- CAS. Nr.: 2845278-33-1
- Formel: C20H19F5N4O2S
- Molecular Weight:474.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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17β-HSD2 2.1 nM (IC50) |
17β-HSD5 0.38 nM (IC50) |
Chemical Information
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CAS. Nr. 2845278-33-1
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Molecular Weight 474.45
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Formel C20H19F5N4O2S
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SMILES
FC1(F)C2=NC(N3[C@@H](C(F)(F)F)CC3)=NC(C4=CC=C(C5(CS(C5)(=O)=O)N)C=C4)=C2CC1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
GS-1291269 Related Classifications
HY-180921 Related Classifications
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