ML350
ML350 (CYM50202) is a highly potent OPRK1 antagonist with selectivity and broad biological applications. With IC50 values of 9-16 nM, ML350 shows high selectivity for OPRK1, with selectivity of 219-382-fold and 20-35-fold relative to OPRD1 and OPRM1, respectively. ML350 exhibited favorable characteristics in in vivo pharmacokinetic analysis, including high passive membrane permeability and moderate human plasma protein binding. Extensive screening of ML350 against multiple ion channels, receptors, and transporters showed that it does not have adverse off-target effects.
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- CAS. Nr.: 1565852-90-5
- Formel: C18H26BrN3O3
- Molecular Weight:412.32
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Chemical Information
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CAS. Nr. 1565852-90-5
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Molecular Weight 412.32
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Formel C18H26BrN3O3
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SMILES
O=C(OC)C1=CC(Br)=CN=C1N2C[C@@H]([C@H](CC2)NC3CCCCC3)O
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Synonyms
CYM50202
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ML350 Related Classifications
HY-116163 Related Classifications
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