N3-C2-NHS ester
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N3-C2-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C2-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- Reinheit: 99.77%
- CAS. Nr.: 850180-76-6
- Formel: C7H8N4O4
- Molecular Weight:212.16
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Speicherung:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Non-cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 850180-76-6
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Appearance Oil
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Molecular Weight 212.16
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Formel C7H8N4O4
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Color Colorless to off-white
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SMILES
O=C(ON1C(CCC1=O)=O)CCN=[N+]=[N-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (471.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7134 mL | 23.5671 mL | 47.1342 mL | 117.8356 mL |
| 5 mM | 0.9427 mL | 4.7134 mL | 9.4268 mL | 23.5671 mL | |
| 10 mM | 0.4713 mL | 2.3567 mL | 4.7134 mL | 11.7836 mL | |
| 15 mM | 0.3142 mL | 1.5711 mL | 3.1423 mL | 7.8557 mL | |
| 20 mM | 0.2357 mL | 1.1784 mL | 2.3567 mL | 5.8918 mL | |
| 25 mM | 0.1885 mL | 0.9427 mL | 1.8854 mL | 4.7134 mL | |
| 30 mM | 0.1571 mL | 0.7856 mL | 1.5711 mL | 3.9279 mL | |
| 40 mM | 0.1178 mL | 0.5892 mL | 1.1784 mL | 2.9459 mL | |
| 50 mM | 0.0943 mL | 0.4713 mL | 0.9427 mL | 2.3567 mL | |
| 60 mM | 0.0786 mL | 0.3928 mL | 0.7856 mL | 1.9639 mL | |
| 80 mM | 0.0589 mL | 0.2946 mL | 0.5892 mL | 1.4729 mL | |
| 100 mM | 0.0471 mL | 0.2357 mL | 0.4713 mL | 1.1784 mL |
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