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Art. -Nr.: HY-W556870

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OT-551

OT-551 is a NF-κB inhibitor with antioxidant and anti-inflammatory effects. OT-551 has the potential for retinal diseases research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 627085-15-8
Formel: C₁₃H₂₄ClNO₃
Molecular Weight:277.79

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

OT-551 Chemical Structure

CAS. Nr.: 627085-15-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

OT-551 is a NF-κB inhibitor with antioxidant and anti-inflammatory effects. OT-551 has the potential for retinal diseases research^[1]^[2].

Alle NF-κB Isoform-spezifische Produkte anzeigen :

In Vivo

OT-551 (25-100 mg/kg; ip; once) provides RPE cell protection against acute light damage in albino rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (SD) albino rats (6-7 weeks of age) exposure to 2700 lux white fluorescent light^[1]
Dosage:

25, 50, or 100 mg/kg
Administration:

ip; once
Result:

Retinal pigment epithelium (RPE) damage index was significantly lower in the animals.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 627085-15-8
Molecular Weight 277.79
Formel C₁₃H₂₄ClNO₃
SMILES

CC1(C)CC(OC(C2CC2)=O)CC(C)(C)N1O.[H]Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Masaki Tanito, et al. Protection of retinal pigment epithelium by OT-551 and its metabolite TEMPOL-H against light-induced damage in rats. Exp Eye Res. 2010 Jul;91(1):111-4. [Content Brief]

[2]. S. A. Mousa, et al. Anti-Angiogenesis Efficacy of the Novel NF-B and Oxidative Stress Inhibitor, OT-551. ARVO Annual Meeting Abstract.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- In Vivo
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise

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Art. -Nr.:
Menge:
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OT-551

High-Throughput Bioactive Compound Library

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