VRK
Named for their resemblance to the vaccinia virus B1R kinase, the VRK members are highly divergent from other CMGC kinases and are not switched on by upstream MAP kinase cascades. VRK1 is a nuclear enzyme that phosphorylates barrier-to-autointegration factor (BAF), histone H3 Thr3, p53 and ATF2, supporting nuclear envelope reassembly, chromatin condensation and DNA damage signaling; recessive VRK1 mutations cause pontocerebellar hypoplasia and motor neuron disease. VRK2 is anchored to the mitochondrial outer membrane and endoplasmic reticulum with isoform-specific pro-apoptotic actions. VRK3 carries degenerate catalytic motifs and acts more as a scaffold that promotes ERK signaling than as a conventional kinase.
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VRK Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
