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Art. -Nr.: HY-112074

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Tiamenidine

Name: Tiamenidine
Brand: MedChemExpress
SKU: HY-112074
Price: 2645.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: HOE 440)

Tiamenidine (HOE 440) is an orally active α-2 adrenoceptor agonist. Tiamenidine stimulates peripheral α-adrenergic receptors, causing a transient increase in blood pressure, and activates central adrenergic receptors, inhibiting sympathetic nerve activity. Tiamenidine lowers blood pressure in hypertensive rats and inhibits plasma renin activity. Tiamenidine reduces ethanol preference and intake in ethanol-preferring rats. Tiamenidine attenuates Xylazine-induced loss of righting reflex. Tiamenidine can be used in research on hypertension.

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CAS. Nr.: 31428-61-2
Formel: C₈H₁₀ClN₃S
Molecular Weight:215.70

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (288 KB)

Tiamenidine Chemical Structure

CAS. Nr.: 31428-61-2

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: α2-Adrenergic Receptor^[1]

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In Vivo

Tiamenidine (1500-3000 μg/kg; oral) reduces 12-hour voluntary ethanol intake and ethanol preference in ethanol-preferring rats^[1].
Tiamenidine reduces blood pressure, plasma norepinephrine, epinephrine, and plasma renin activity^[2].
Tiamenidine (0.04-10 mg/kg; subcutaneous injection; single administration) partially antagonizes Xylazine-induced loss of righting reflex, but does not produce complete blockade^[3].
Tiamenidine produces partial central nervous system depression, moderate muscle relaxation, and hypothermia in healthy rats, with an ED₅₀ value of 0.73 mg/kg for impairment of the righting reflex, 0.12 mg/kg for muscle relaxation, and 0.32 mg/kg for hypothermia^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (female, 220-270 g)^[3]
Dosage:

0.04, 0.16, 0.63, 2.5, and 10 mg/kg
Administration:

s.c.; single administration; 60 min before observation
Result:

Partially antagonized xylazine‑induced loss of righting reflex with ED₅₀ = 1.7 mg/kg.

Related Protocols :

Research Protocol for Cardiovascular Diseases

Chemical Information

CAS. Nr. 31428-61-2
Molecular Weight 215.70
Formel C₈H₁₀ClN₃S
SMILES

CC1=CSC(Cl)=C1NC2=NCCN2
Synonyms

HOE 440
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (288 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Opitz K, et al. The effect of clonidine and related substances on voluntary ethanol consumption in rats. Drug and alcohol dependence. 1990 Feb;25(1):43-8.

[2]. Hansson BG, et al. Changes in blood pressure, plasma catecholamines and plasma renin activity during and after treatment with tiamenidine and clonidine. British journal of clinical pharmacology. 1981 Jan;11(1):73-7.

[3]. Colpaert FC. Effects of putative α‐adrenoceptor antagonists and of other compounds on the loss of the righting reflex and on exophthalmia induced by xylazine in the rat. Drug development research. 1986 Feb;7(2):125-40.

[4]. Colpaert FC. Maximal magnitude of effect and potency of putative α‐adrenoceptor agonists in causing CNS depression, et al. Drug development research. 1986 Mar;7(3):209-20.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
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- In Vivo
Chemical Information
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Tiamenidine

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