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Cucurbitacin B

11 Cited Publications
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Based on 11 publication(s) in Google Scholar

Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity.

For research use only. We do not sell to patients.

  • Purity: 99.81%
  • CAS No.: 6199-67-3
  • Formula: C32H46O8
  • Molecular Weight:558.70
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Cucurbitacin B Chemical Structure
    Cucurbitacin B Chemical Structure
  • Experimental Validation Results for Cucurbitacin B
  • Experimental Validation Results for Cucurbitacin B
  • Experimental Validation Results for Cucurbitacin B
  • Experimental Validation Results for Cucurbitacin B
  • Experimental Validation Results for Cucurbitacin B
CAS No.: 6199-67-3
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  • Cucurbitacin B Chemical Structure
    Cucurbitacin B Chemical Structure
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    Cucurbitacin B purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Aug 28;25(17):9333. [Abstract]

    Customer Validation
     Effect of Cucurbitacin B (Cu B) on the cell viability of WPMY-1 and HPRF. Cu B and Doxa inhibited the proliferation of WPMY-1 and HPRF cells based on CCK-8 results. Prostate cells were treated with vehicle (0.1% DMSO), doxazosin (40 μM), or Cu B (12.5 nM, 25 nM, 50 nM, 100 nM, 200 nM) for 48 h and 72 h. The positive control drug doxazosin 40 μM significantly reduced the survival rate of both cells compared with the solvent control group. After 72 h of treatment with Cu B at medium to high concentrations (25 nM–200 nM), the survival rate of WPMY-1 cells was significantly reduced compared with the solvent control group. Only after 72 h of treatment with the highest concentration (200 nM) of Cu B was the survival rate of HPRF cells significantly reduced compared with the solvent control group.

  • 1/16

    Cucurbitacin B purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Aug 28;25(17):9333. [Abstract]

    Customer Validation
     Apoptosis of WPMY-1 and HPRF that were treated with Cucurbitacin B (Cu B) and Doxa. Cu B and Doxa induced the apoptosis of prostate cells based on the results of flow cytometry analysis. In WPMY-1 cells, the apoptosis rate of the Doxa group and the middle-to-high concentration Cu B (50 nM–100 nM; 48 h) group was significantly increased compared with the control group. In HPRF cells, only the apoptosis rate of the high-concentration Cu B (50 nM–100 nM; 48 h) group was significantly increased compared with the control group.

  • 1/16

    Cucurbitacin B purchased from MedChemExpress. Usage Cited in: Mech Ageing Dev. 2020 Oct;191:111347. [Abstract]

    Customer Validation
     H2O2-treated NIH3T3 cells were incubated in complete medium with different STAT3 inhibitors including AG490 (50 μM), Stattic (0.5 μM), Cucurbitacin B (CuB, 40 ng/mL), S3I-201 (50 μM) and NF-κB inhibitor QNZ (5 μM) for 3 days. Cells lysates were subjected to immunoblotting. The results showed that Cucurbitacin B reduced the expression of p21.

  • 1/16

    Cucurbitacin B purchased from MedChemExpress. Usage Cited in: Mech Ageing Dev. 2020 Oct;191:111347. [Abstract]

    Customer Validation
     H2O2-treated NIH3T3 cells were incubated in complete medium with different STAT3 inhibitors including AG490 (50 μM), Stattic (0.5 μM), Cucurbitacin B (CuB, 40 ng/mL), S3I-201 (50 μM) and NF-κB inhibitor QNZ (5 μM) for 3 days. Cells were stained for SA-β-Gal and quantified.

  • 1/16

    Cucurbitacin B purchased from MedChemExpress. Usage Cited in: Mech Ageing Dev. 2020 Oct;191:111347. [Abstract]

    Customer Validation
     H2O2-treated NIH3T3 cells were incubated in complete medium with different STAT3 inhibitors including AG490 (50 μM), Stattic (0.5 μM), Cucurbitacin B (CuB, 40 ng/mL), S3I-201 (50 μM) and NF-κB inhibitor QNZ (5 μM) for 3 days. qRT-PCR analyses of SASP factors expression.

  • Cucurbitacin B