Dazostinag
Based on 1 publication(s) in Google Scholar
Dazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis antibody-drug conjugates (ADCs).
The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Dazostinag disodium) that retains the same biological activity.
For research use only. We do not sell to patients.
- CAS No.: 2553413-86-6
- Formula: C21H22F2N8O10P2S2
- Molecular Weight:710.52
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Dazostinag
More
Biological Activity
Description
In Vitro
Dazostinag (ADC-1, linker-payload) (121 μM; 10 min-24 hr) exhibits an half-life (t1/2) of 2.4 hr in rat liver tritosomes[1].
Dazostinag (ADC-1, linker-payload) activates human Guanylyl cyclase C (GCC) with an EC50 value of 0.068 nM in THPl cells with R232 variant of human STING[1].
Dazostinag (ADC-1) (10 μg/mL; 0-96 hr) shows plasma stability in human, primate and mouse plasma[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Dazostinag (ADC-1) (50 μg/kg, 100 μg/kg; i.v.; single dose, monitored for 2 weeks) significantly inhibits the growth of tumor in Balb/C mouse bearing GCC-expressing CT26 colon carcinoma mouse tumors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:CT26 colon carcinoma model in female Balb/C mice (6-8 weeks old)[1]
-
Dosage:50 μg/kg, 100 μg/kg
-
Administration:IP; single dose, monitored for 15 days, measured two times per week
-
Result:Significantly suppressed the volume of tumor in mice.
Chemical Information
-
CAS No. 2553413-86-6
-
Molecular Weight 710.52
-
Formula C21H22F2N8O10P2S2
-
SMILES
FC1=CN([C@H]2[C@H](O[P@@](OC[C@@H]3[C@@H](O4)[C@@H](F)[C@H](N5C6=NC=NC(N)=C6N=C5)O3)(S)=O)[C@H](O)[C@@H](COP4(S)=O)O2)C7=C1C(N=CN7)=O
-
Synonyms
TAK-676 free base
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Science
2026 May 7;392(6798):eadx1893. PMID: 42096576
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dazostinag Related Classifications
HY-152861 Related Classifications
Powered by Bioz