SEC23A - SEC23 homolog A, COPII coat complex component Gene

Also Known as CLSD; hSec23A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10484

About SEC23A

Cytogenetic location: 14q21.1 Genomic coordinates (GRCh38): 14:39,031,919-39,103,235 (from NCBI)

This gene has 15 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in duodenum (RPKM 27.6), small intestine (RPKM 25.4) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]

SEC23A Products (1)

mRNA	Protein	Name
NM_006364.4	NP_006355.2	protein transport protein Sec23A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10075675	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	18843296	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in COPII-coated vesicle cargo loading	IDA IDA: Inferred from direct assay	17499046	GOA
involved in COPII-coated vesicle cargo loading	IGI IGI: Inferred from genetic interaction	8898360	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of COPII vesicle coat	IDA IDA: Inferred from direct assay	17499046	GOA
located in ER to Golgi transport vesicle membrane	IGI IGI: Inferred from genetic interaction	8898360	GOA
located in cytosol	IDA IDA: Inferred from direct assay	8898360	GOA
located in endoplasmic reticulum exit site	IDA IDA: Inferred from direct assay	8898360	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC23A Protein Structure

zf-Sec23_Sec24

Sec23_trunk

Sec23_BS

Sec23_helical

Gelsolin

0
200
400
600
765 a.a.

Protein Preferred Names	Protein Names
protein transport protein Sec23A	SEC23-related protein A

SEC23A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SEC23A	Q15436	CADPS	Homo sapiens	A2RRN7	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	CADPS	Homo sapiens	A2RRN7	Y2H Array	32296183
Intra	SEC23A	Q15436	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	SEC23A	Q15436	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	SEC23A	Q15436	CLEC17A	Homo sapiens	Q6ZS10	Y2H Array	32296183
Intra	SEC23A	Q15436	CLEC17A	Homo sapiens	Q6ZS10	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	CLEC17A	Homo sapiens	Q6ZS10	Validated Y2H	32296183
Intra	SEC23A	Q15436	MINAR1	Homo sapiens	Q9UPX6	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	MINAR1	Homo sapiens	Q9UPX6	Validated Y2H	32296183
Intra	SEC23A	Q15436	MINAR1	Homo sapiens	Q9UPX6	Y2H Array	32296183
Intra	SEC23A	Q15436	SF1	Homo sapiens	Q15637-4	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	SF1	Homo sapiens	Q15637-4	Validated Y2H	32296183
Intra	SEC23A	Q15436	SF1	Homo sapiens	Q15637-4	Y2H Array	32296183
Intra	SEC23A	Q15436	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	SEC23A	Q15436	SEC23IP	Homo sapiens	Q9Y6Y8	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	SEC23IP	Homo sapiens	Q9Y6Y8	Y2H Array	32296183
Intra	SEC23A	Q15436	SEC23IP	Homo sapiens	Q9Y6Y8	Validated Y2H	32296183
Intra	SEC23A	Q15436	SEC23IP	Homo sapiens	Q9Y6Y8	Anti Tag CoIP	33961781
Intra	SEC23A	Q15436	SUCLA2	Homo sapiens	Q9P2R7	Validated Y2H	32296183
Intra	SEC23A	Q15436	MIA3	Homo sapiens	Q5JRA6	Validated Y2H	32296183
Intra	SEC23A	Q15436	MIA3	Homo sapiens	Q5JRA6	Y2H Array	32296183
Intra	SEC23A	Q15436	MIA3	Homo sapiens	Q5JRA6	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	RNF19B	Homo sapiens	Q6ZMZ0	Validated Y2H	32296183
Intra	SEC23A	Q15436	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
Intra	SEC23A	Q15436	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	DNM2	Homo sapiens	P50570	Y2H Array	32296183
Intra	SEC23A	Q15436	DNM2	Homo sapiens	P50570	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
Intra	SEC23A	Q15436	ERLIN1	Homo sapiens	O75477	Y2H Array	32296183
Intra	SEC23A	Q15436	ERLIN1	Homo sapiens	O75477	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	TMEM45B	Homo sapiens	Q96B21	Validated Y2H	32296183
Intra	SEC23A	Q15436	TMEM45B	Homo sapiens	Q96B21	Y2H Array	32296183
Intra	SEC23A	Q15436	TMEM45B	Homo sapiens	Q96B21	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	SLC7A1	Homo sapiens	P30825	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	SLC7A1	Homo sapiens	P30825	Y2H Array	32296183
Intra	SEC23A	Q15436	FASLG	Homo sapiens	P48023	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	FASLG	Homo sapiens	P48023	Y2H Array	32296183
Intra	SEC23A	Q15436	TNFSF14	Homo sapiens	O43557	Y2H Array	32296183
Intra	SEC23A	Q15436	TNFSF14	Homo sapiens	O43557	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	WBP11	Homo sapiens	Q9Y2W2	Validated Y2H	32296183
Intra	SEC23A	Q15436	WBP11	Homo sapiens	Q9Y2W2	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	WBP11	Homo sapiens	Q9Y2W2	Y2H Array	32296183
Intra	SEC23A	Q15436	CDK16	Homo sapiens	Q00536	Anti Bait CoIP	16091426
Intra	SEC23A	Q15436	CDK16	Homo sapiens	Q00536	Y2H	16091426
Intra	SEC23A	Q15436	DTX2	Homo sapiens	Q86UW9	Y2H Array	32296183
Intra	SEC23A	Q15436	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
Intra	SEC23A	Q15436	SEC23B	Homo sapiens	Q15437	Validated Y2H	32296183
Intra	SEC23A	Q15436	SEC23B	Homo sapiens	Q15437	Anti Tag CoIP	33961781
Intra	SEC23A	Q15436	SEC23B	Homo sapiens	Q15437	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	SEC23B	Homo sapiens	Q15437	Y2H Array	32296183
Intra	SEC23A	Q15436	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	SEC23A	Q15436	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	SEC23A	Q15436	SEC24D	Homo sapiens	O94855	Anti Tag CoIP	33961781
Intra	SEC23A	Q15436	SEC24D	Homo sapiens	O94855	Anti Tag CoIP	35271311
Intra	SEC23A	Q15436	BNIP3	Homo sapiens	Q12983	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	BNIP3	Homo sapiens	Q12983	Y2H Array	32296183
Intra	SEC23A	Q15436	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	SEC23A	Q15436	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	SEC23A	Q15436	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	SEC23A	Q15436	SEC24B	Homo sapiens	O95487	Anti Tag CoIP	35271311
Intra	SEC23A	Q15436	SEC24B	Homo sapiens	O95487	Anti Tag CoIP	33961781
Intra	SEC23A	Q15436	SEC24C	Homo sapiens	P53992	Cosedimentation	18692470
Intra	SEC23A	Q15436	SEC24C	Homo sapiens	P53992	Anti Tag CoIP	33961781
Intra	SEC23A	Q15436	SEC24C	Homo sapiens	P53992	EM	18692470
Intra	SEC23A	Q15436	SEC24C	Homo sapiens	P53992	Y2H	10075675

Cross: Cross-species interaction Intra: Intraspecies interaction

SEC23A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81799	SEC23A Antibody (YA1544)	WB, FC	Human

Related Diseases

Diseases	Alias
Craniolenticulosutural Dysplasia	Boyadjiev-Jabs Syndrome CLSD Cranio-Lenticulo-Sutural Dysplasia Cranio-Lenticulo-Sutural Dysplasia, Clsd
Spondyloepiphyseal Dysplasia Tarda, X-Linked	Spondyloepiphyseal Dysplasia Tarda X-Linked Spondyloepiphyseal Dysplasia Tarda SEDT Sed Tarda, X-Linked Spondyloepiphyseal Dysplasia, Late Spondyloepiphyseal Dysplasia Tarda X-Linked Sed X Linked Spondyloepiphyseal Dysplasia Tarda X-Linked Spondyloepiphyseal Dysplasia Late Onset Spondyloepiphyseal Dysplasia Sed Tarda X-Linked Sed X-Linked Sedt Dysplasia, Spondyloepiphyseal, Tarda Spondyloepiphyseal Dysplasia
Anemia, Congenital Dyserythropoietic, Type Ii	Congenital Dyserythropoietic Anemia Type Ii CDAN2 Cda Ii Hereditary Erythroblastic Multinuclearity With Positive Acidified-Serum Test Cda Type Ii Congenital Dyserythropoietic Anemia Type 2 Hereditary Erythroblastic Multinuclearity With A Positive Acidified-Serum Test Sec23b-Cdg Congenital Dyserythropoietic Anemia, Type Ii Dyserythropoietic Anemia, Hempas Type Hempas Cda Type 2 Dyserythropoietic Anemia, Congenital, Type Ii Cda, Type Ii Congenital Dyserythropoietic Anaemia Type 2 Congenital Dyserythropoietic Anaemia Type Ii Anemia, Dyserythropoietic, Congenital Type 2 Hempas Anemia Dyserythropoietic Anemia, Congenital Type 2 Anemia, Congenital Dyserythropoietic, 2 Dyserythropoietic Anemia Hempas Type Anemia, Dyserythropoietic Congenital, Type Ii Anemia, Dyserythropoietic, Congenital, Type Ii
Camptodactyly-Tall Stature-Scoliosis-Hearing Loss Syndrome	Catshl Syndrome Camptodactyly-Tall Stature-Scoliosis-Deafness Syndrome
Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type	Spondyloepimetaphyseal Dysplasia-Short Limb-Abnormal Calcification Syndrome Smed-Sl Smed-Sl/Ac Smed Short Limb-Abnormal Calcification Type Smed Short Limb-Hand Type Spondylometaepiphyseal Dysplasia Short Limb-Hand Type Smed, Type Ii Smed Type 2 Spondylometaepiphyseal Dysplasia Short Limb-Abnormal Calcification Type Smed, Short Limb-Hand Type Spondylometaepiphyseal Dysplasia, Short Limb-Abnormal Calcification Type Smed, Short Limb-Abnormal Calcification Type Spondyloepimetaphyseal Dysplasia - Short Limb - Abnormal Calcification Spondyloepimetaphyseal Dysplasia, Short Limb-Hand Type SEMD-SL Smed Type Ii Dysplasia, Spondylometaepiphyseal, Short Limb-Hand Type
Cole-Carpenter Syndrome	Cole Carpenter Syndrome Bone Fragility Craniosynostosis Proptosis Hydrocephalus Bone Fragility With Craniosynostosis, Ocular Proptosis, Hydrocephalus, And Distinctive Facial Features Bone Fragility-Craniosynostosis-Proptosis-Hydrocephalus Syndrome
Spondyloepiphyseal Dysplasia Congenita	SEDC Sed Congenita Spondyloepiphyseal Dysplasia, Congenital Type Late Spondyloepiphyseal Dysplasia Sed, Congenital Type Congenital Spondyloepiphyseal Dysplasia Spranger-Wiedemann Disease Spondyloepiphyseal Dysplasia Congenital Type Dysplasia, Spondyloepiphyseal, Congenita Spondyloepiphyseal Dysplasia, Congenita Spondyloepiphyseal Dysplasia Tarda, X-Linked
Geroderma Osteodysplasticum	Gerodermia Osteodysplastica Geroderma Osteodysplastica GO Walt Disney Dwarfism Type Of Gerodermia Osteodysplastica

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12612	SEC23A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SEC23A	RGD	RGD:1309103
Bos taurus	SEC23A	VGNC	VGNC:34410
Canis familiaris	SEC23A	VGNC	VGNC:45969
Mus musculus	SEC23A	MGD	MGI:1349635
Felis catus	SEC23A	VGNC	VGNC:64966
Macaca mulatta	SEC23A	VGNC	VGNC:77150
Others	SEC23A	NCBI