INPP5D - inositol polyphosphate-5-phosphatase D Gene

Also Known as SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3635

About INPP5D

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,060,342-233,207,903 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 215 orthologues and 13 paralogues. Broad expression in lymph node (RPKM 33.2), spleen (RPKM 31.1) and 21 other tissues.

Summary

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol Phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]

INPP5D Products (2)

mRNA Protein Name
NM_001017915.3 NP_001017915.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform a
NM_005541.5 NP_005532.2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9148918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INPP5D Protein Structure

Exo_endo_phos

Exo_endo_phos: Endonuclease/Exonuclease/phosphatase family (30 - 322)

  • 0
  • 200
  • 400
  • 600
  • 810 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

  • SH2 domain-containing inositol 5'-phosphatase 1

INPP5D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
INPP5D Q92835 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
INPP5D Q92835 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
Intra
INPP5D Q92835 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra
INPP5D Q92835 CD244 Homo sapiens Q9BZW8
SPR
24642916
Intra
INPP5D Q92835 SH3KBP1 Homo sapiens Q96B97
Anti Tag CoIP
15090612
Intra
INPP5D Q92835 KHDRBS3 Homo sapiens O75525
Y2H Prey Pooling
25416956
Intra
INPP5D Q92835 KHDRBS3 Homo sapiens O75525
Y2H Array
25416956
Intra
INPP5D Q92835 FCGR2B Homo sapiens P31994
SPR
24642916
Intra
INPP5D Q92835 FCGR2B Homo sapiens P31994
Affinity Chrom
9148918
Intra
INPP5D Q92835 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
INPP5D Q92835 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

INPP5D Antibodies

Cat. No. Product Name Application Reactivity
HY-P83087 SHIP1 Antibody (YA2832) WB, IHC-P, IP, FC Human
HY-P83344 Phospho-SHIP1 (Tyr1020) Antibody (YA3089) WB, ICC/IF, IP Human

Related Diseases

Diseases Alias
Crohn'S Disease

  • Crohn Disease

  • Pediatric Crohn'S Disease

  • Regional Enteritis

  • Crohn'S Disease Of Large Bowel

  • Granulomatous Colitis

  • Enteritis, Granulomatous

  • Enteritis

  • Crohn'S Disease Of Colon

  • Colitis, Granulomatous

  • Crohn'S Enteritis

  • Enteritis, Regional

  • Ileitis

  • Adenoviral Enteritis

  • Acute Gastroenteropathy Due To Norwalk Agent

  • Viral Gastroenteritis Due To Norwalk Agent

  • Winter Vomiting

  • Epidemic Winter Vomiting Disease

  • Small Round Structured Virus Enteritis

  • Epidemic Vomiting Syndrome

  • Epidemic Vomiting

  • Epidemic Nausea

  • Epidemic Viral Gastroenteritis Due To Norwalk Virus

  • Noroviral Enteritis

  • Crohn Disease Nos

  • Crohns

  • Cd - [Crohn'S Disease]

  • Regional Enteritis Of Bowel

  • Crohn'S Regional Enteritis

  • Cobble-Stone Appearance Of Intestine

  • Intestinal Ulcer And Erosion Due To Crohn Disease

  • Granulomatous Enteritis
Lymphoproliferative Syndrome

  • Lymphoproliferative Disorder

  • Lymphoproliferative Disorders

  • Lymphoproliferative Disorders, Susceptibility To
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Juvenile Myelomonocytic Leukemia

  • Leukemia, Juvenile Myelomonocytic

  • JMML

  • Leukemia, Juvenile Myelomonocytic, Somatic

  • Juvenile Chronic Myelomonocytic Leukemia

  • Juvenile Chronic Myelogenous Leukemia

  • Leukemia, Myelomonocytic, Juvenile

  • Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Severe Congenital Neutropenia

  • Congenital Neutropenia

  • Neutropenia, Severe Congenital

  • Congenital Agranulocytosis

  • Infantile Genetic Agranulocytosis

  • Kostmann Disease

  • Kostmann'S Agranulocytosis

  • Kostmann'S Syndrome

  • Severe Infantile Genetic Neutropenia
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

  • Nasu-Hakola Disease

  • Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

  • Plosl

  • Nhd

  • Presenile Dementia With Bone Cysts

  • Plo-Sl

  • PLOSL1

  • Dementia, Prefrontal, With Bone Cysts

  • Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

  • Brain-Bone-Fat Disease

  • Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

  • Brain-Bone-Fat Disease
Leukemia, Chronic Myeloid

  • Chronic Myeloid Leukemia

  • Chronic Myelogenous Leukemia

  • CML

  • Chronic Granulocytic Leukemia

  • Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

  • Chronic Myeloid Leukaemia

  • Chronic Granulocytic Leukaemia

  • Chronic Myelogenous Leukaemia

  • Myeloid Leukemia, Chronic

  • Leukemia, Chronic Myelogenous

  • Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

  • Cml - Chronic Myelogenous Leukemia

  • Cgl

  • Chronic Myelocytic Leukemia

  • Leukemia, Chronic Myeloid, Atypical

  • ACML

  • Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

  • Myeloid Leukemia Chronic

  • Leukemia, Myeloid, Chronic

  • Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

  • Cml- [Chronic Myeloid Leukaemia]

  • Cgl - [Chronic Granulocytic Leukaemia]

  • Chronic Myelocytic Leukaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS21142 Inpp5d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06829 INPP5D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27659 Inpp5d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus INPP5D VGNC VGNC:67809
Mus musculus INPP5D MGD MGI:107357
Bos taurus INPP5D VGNC VGNC:30212
Macaca mulatta INPP5D VGNC VGNC:73751
Canis familiaris INPP5D VGNC VGNC:42032
Rattus norvegicus INPP5D RGD RGD:2914
Others INPP5D NCBI