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VDAC2 - voltage dependent anion channel 2 Gene

Also Known as POR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7417

About VDAC2

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:75,210,170-75,231,448 (from NCBI)

This gene has 14 transcripts (splice variants), 237 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 81.3), esophagus (RPKM 66.2) and 25 other tissues.

Summary

This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

VDAC2 Products (8)

mRNA	Protein	Name
NM_001184783.3	NP_001171712.1	voltage-dependent anion-selective channel protein 2 isoform 1
NM_001184823.2	NP_001171752.1	voltage-dependent anion-selective channel protein 2 isoform 2
NM_001324087.2	NP_001311016.1	voltage-dependent anion-selective channel protein 2 isoform 3
NM_001324088.2	NP_001311017.1	voltage-dependent anion-selective channel protein 2 isoform 2
NM_001324089.2	NP_001311018.1	voltage-dependent anion-selective channel protein 2 isoform 3
NM_001324090.2	NP_001311019.1	voltage-dependent anion-selective channel protein 2 isoform 3
NM_001391963.1	NP_001378892.1	voltage-dependent anion-selective channel protein 2 isoform 2
NM_003375.5	NP_003366.2	voltage-dependent anion-selective channel protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ceramide binding	IDA IDA: Inferred from direct assay	31015432	GOA
enables cholesterol binding	IDA IDA: Inferred from direct assay	31015432	GOA
enables phosphatidylcholine binding	IDA IDA: Inferred from direct assay	31015432	GOA
enables phospholipid scramblase activity	IDA IDA: Inferred from direct assay	38065946	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15082785	GOA
enables voltage-gated monoatomic anion channel activity	IDA IDA: Inferred from direct assay	8420959	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in binding of sperm to zona pellucida	IMP IMP: Inferred from mutant phenotype	23355646	GOA
involved in mitochondrial outer membrane permeabilization	IMP IMP: Inferred from mutant phenotype	31015432	GOA
involved in mitochondrial transmembrane transport	IDA IDA: Inferred from direct assay	38065946	GOA
involved in monoatomic anion transport	IDA IDA: Inferred from direct assay	8420959	GOA
involved in phospholipid translocation	IDA IDA: Inferred from direct assay	38065946	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	23355646	GOA
located in membrane	IDA IDA: Inferred from direct assay	27641616	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	25204797	GOA
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	31015432	GOA
located in mitochondrial nucleoid	IDA IDA: Inferred from direct assay	18063578	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	7539795	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VDAC2 Protein Structure

Porin_3

0
100
200
294 a.a.

Protein Preferred Names	Protein Names
voltage-dependent anion-selective channel protein 2	epididymis secretory sperm binding protein

VDAC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VDAC2	P45880	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	VDAC2	P45880	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	VDAC2	P45880	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	VDAC2	P45880	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	VDAC2	P45880	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	VDAC2	P45880	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	VDAC2	P45880	CTSD	Homo sapiens	P07339	Validated Y2H	32814053
Intra	VDAC2	P45880	CTSD	Homo sapiens	P07339	Y2H Array	32814053
Intra	VDAC2	P45880	CTSD	Homo sapiens	P07339	Y2H Pooling	32814053
Intra	VDAC2	P45880	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	VDAC2	P45880	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	VDAC2	P45880	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	VDAC2	P45880	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	VDAC2	P45880	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	VDAC2	P45880	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	VDAC2	P45880	VDAC3	Homo sapiens	Q9Y277	Crosslink	30021884
Intra	VDAC2	P45880	CCT5	Homo sapiens	P48643	Y2H Pooling	32814053
Intra	VDAC2	P45880	CCT5	Homo sapiens	P48643	Validated Y2H	32814053
Intra	VDAC2	P45880	CCT5	Homo sapiens	P48643	Y2H Array	32814053
Intra	VDAC2	P45880	TPPP	Homo sapiens	O94811	Y2H Array	32814053
Intra	VDAC2	P45880	TPPP	Homo sapiens	O94811	Y2H Pooling	32814053
Intra	VDAC2	P45880	TPPP	Homo sapiens	O94811	Validated Y2H	32814053
Intra	VDAC2	P45880	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	VDAC2	P45880	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	VDAC2	P45880	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	VDAC2	P45880	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	VDAC2	P45880	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	VDAC2	P45880	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	VDAC2	P45880	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	VDAC2	P45880	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	VDAC2	P45880	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	VDAC2	P45880	EEF1D	Homo sapiens	P29692-2	Y2H Array	32814053
Intra	VDAC2	P45880	EEF1D	Homo sapiens	P29692-2	Validated Y2H	32814053
Intra	VDAC2	P45880	EEF1D	Homo sapiens	P29692-2	Y2H Pooling	32814053
Intra	VDAC2	P45880	FAM162A	Homo sapiens	Q96A26	Anti Bait CoIP	15082785
Intra	VDAC2	P45880	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
Intra	VDAC2	P45880	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
Intra	VDAC2	P45880	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
Intra	VDAC2	P45880	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	VDAC2	P45880	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	VDAC2	P45880	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	VDAC2	P45880	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	VDAC2	P45880	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	VDAC2	P45880	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	VDAC2	P45880	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	VDAC2	P45880	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	VDAC2	P45880	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	VDAC2	P45880	NDUFV1	Homo sapiens	P49821	Y2H Pooling	32814053
Intra	VDAC2	P45880	NDUFV1	Homo sapiens	P49821	Validated Y2H	32814053
Intra	VDAC2	P45880	NDUFV1	Homo sapiens	P49821	Y2H Array	32814053
Intra	VDAC2	P45880	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	VDAC2	P45880	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	VDAC2	P45880	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	VDAC2	P45880	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	VDAC2	P45880	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053
Intra	VDAC2	P45880	PEX1	Homo sapiens	O43933	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
3-Methylglutaconic Aciduria, Type Iii	Optic Atrophy 3-Methylglutaconic Aciduria Type 3 Costeff Syndrome Mga3 Costeff Optic Atrophy Syndrome Optic Atrophy Plus Syndrome Infantile Optic Atrophy With Chorea And Spastic Paraplegia 3-Methylglutaconic Aciduria Type Iii Autosomal Recessive Optic Atrophy Plus Syndrome Autosomal Recessive Optic Atrophy Type 3 Opa3 Defect MGCA3 Mga, Type Iii Iraqi Jewish Optic Atrophy Plus Mga Type Iii Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia Iraqi-Jewish 'Optic Atrophy Plus' Optic Atrophy 3, Autosomal Recessive Opa3, Autosomal Recessive Opa3-Related 3-Methylglutaconic Aciduria Iraqi-Jewish Optic Atrophy Plus Atrophy Of Optic Disc 3-Alpha Methylglutaconic Aciduria Type Iii Optic Atrophy 3 Optic Atrophy Infantile With Chorea And Spastic Paraplegia Autosomal Recessive Opa3 Autosomal Recessive Optic Atrophy 3 3-Methylglutaconic Aciduria 3 3-Alpha-Methylglutaconic Aciduria Type 3 Optic Atrophy 3 Autosomal Recessive Atrophy, Optic Atrophy, Optic, Plus Syndrome Optic Nerve Atrophy Primary Optic Atrophy Oa - [Optic Atrophy] Second Cranial Nerve Atrophy Second Cranium Nerve Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15763	Erastin	Inhibitor	99.91%	Unkown
HY-128777	WEHI-9625	Inhibitor	99.46%	Unkown
HY-172262	WEHI-3773	Ligand	99.89%	Unkown
HY-181529	NCATS-SM0225	Ligand	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VDAC2	MGD	MGI:106915
Rattus norvegicus	VDAC2	RGD	RGD:621576
Bos taurus	VDAC2	VGNC	VGNC:36783
Macaca mulatta	VDAC2	VGNC	VGNC:78763
Canis familiaris	VDAC2	VGNC	VGNC:48247
Felis catus	VDAC2	VGNC	VGNC:97682
Others	VDAC2	NCBI