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Cat. No.: HY-156614

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Icalcaprant

Icalcaprant is a kappa-opioid receptor antagonist.

For research use only. We do not sell to patients.

CAS No.: 2227384-17-8
Formula: C₂₃H₂₆N₄O₃
Molecular Weight:406.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Icalcaprant Chemical Structure

CAS No.: 2227384-17-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Icalcaprant is a kappa-opioid receptor antagonist^[1].

IC₅₀ & Target

kappa-opioid receptor^[1]

All Opioid Receptor Isoforms :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 2227384-17-8
Molecular Weight 406.48
Formula C₂₃H₂₆N₄O₃
SMILES

COC(C([C@H](CCC1)N1CC2=CC=C(C=C2)OC3=CC=C(C=C3)C(N)=O)=C4)=NN4C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Arora, et al. Preparation of heteroarylphenoxy benzamide κ-opioid ligands for the treatment of neurological and psychiatric disorders. World Intellectual Property Organization, WO2018096510 A1. 2018-05-31.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- Clinical Trial
Chemical Information
Purity & Documentation
References

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Icalcaprant

All Opioid Receptor Isoforms