Isorosmanol
Based on 1 publication(s) in Google Scholar
Isorosmanol is an abietane-type diterpene isolated from Rosmarinus officinalis L. aerial parts, with antioxidant, neuroprotective and neurotrophic effects. Isorosmanol inhibits AChE activity and melanin synthesis.
For research use only. We do not sell to patients.
- Purity: 99.66%
- CAS No.: 93780-80-4
- Formula: C20H26O5
- Molecular Weight:346.42
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Isorosmanol
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Biological Activity
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AChE |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | GI50 |
19 μM
Compound: 4
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Cytotoxicity against human A2780 cells after 48 hrs by SRB assay
Cytotoxicity against human A2780 cells after 48 hrs by SRB assay
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[PMID: 17190465] |
| A549 | IC50 |
>60 μM
Compound: 12
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Cytotoxicity against human A549 cells at lag phase of growth after 48 hrs by MTT assay
Cytotoxicity against human A549 cells at lag phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| A549 | IC50 |
46 μM
Compound: 12
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Cytotoxicity against human A549 cells at exponential phase of growth after 48 hrs by MTT assay
Cytotoxicity against human A549 cells at exponential phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| HBL-100 | GI50 |
17 μM
Compound: 4
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Cytotoxicity against human HBL100 cells after 48 hrs by SRB assay
Cytotoxicity against human HBL100 cells after 48 hrs by SRB assay
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[PMID: 17190465] |
| HeLa | IC50 |
>60 μM
Compound: 12
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Cytotoxicity against human HeLa cells at exponential phase of growth after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells at exponential phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| HeLa | IC50 |
>60 μM
Compound: 12
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Cytotoxicity against human HeLa cells at lag phase of growth after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells at lag phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| MCF7 | IC50 |
36.1 μM
Compound: 12
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Cytotoxicity against human sMCF7 cells at exponential phase of growth after 48 hrs by MTT assay
Cytotoxicity against human sMCF7 cells at exponential phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| MCF7 | IC50 |
54.3 μM
Compound: 12
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Cytotoxicity against human MCF7 cells at lag phase of growth after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells at lag phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| SW1573 | GI50 |
23 μM
Compound: 4
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Cytotoxicity against human SW1573 cells after 48 hrs by SRB assay
Cytotoxicity against human SW1573 cells after 48 hrs by SRB assay
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[PMID: 17190465] |
| T47D | GI50 |
>100 μM
Compound: 4
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Cytotoxicity against human T47D cells after 48 hrs by SRB assay
Cytotoxicity against human T47D cells after 48 hrs by SRB assay
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[PMID: 17190465] |
| Vero | IC50 |
>60 μM
Compound: 12
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Cytotoxicity against african green monkey Vero cells at exponential phase of growth after 48 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells at exponential phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| Vero | IC50 |
>60 μM
Compound: 12
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Cytotoxicity against african green monkey Vero cells at lag phase of growth after 48 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells at lag phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| WiDr | GI50 |
>100 μM
Compound: 4
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Cytotoxicity against human WiDr cells after 48 hrs by SRB assay
Cytotoxicity against human WiDr cells after 48 hrs by SRB assay
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[PMID: 17190465] |
Chemical Information
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CAS No. 93780-80-4
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Appearance Solid
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Molecular Weight 346.42
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Formula C20H26O5
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Color White to off-white
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SMILES
O=C1O[C@]2([H])C3=C(C(O)=C(O)C(C(C)C)=C3)[C@@]41CCCC(C)(C)[C@]4([H])[C@H]2O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Biomed Pharmacother
Advances in identifying functional groups in carnosol analogues to address their efficacy in skeletal muscle function. [Abstract]2025 Sep:190:118397. PMID: 40753935
Solvent & Solubility
DMSO : 100 mg/mL (288.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
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Handling Instructions (2659 KB)
References
[1]. Miura K, et al. Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. J Agric Food Chem. 2002 Mar 27;50(7):1845-51. [Content Brief]
[2]. Park SY, et al. Neuroprotective and neurotrophic effects of isorosmanol. Z Naturforsch C. 2009 May-Jun;64(5-6):395-8. [Content Brief]
[3]. Sallam A, et al. Acetylcholine esterase inhibitors and melanin synthesis inhibitors from Salvia officinalis. Phytomedicine. 2016 Sep 15;23(10):1005-11. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8867 mL | 14.4333 mL | 28.8667 mL | 72.1667 mL |
| 5 mM | 0.5773 mL | 2.8867 mL | 5.7733 mL | 14.4333 mL | |
| 10 mM | 0.2887 mL | 1.4433 mL | 2.8867 mL | 7.2167 mL | |
| 15 mM | 0.1924 mL | 0.9622 mL | 1.9244 mL | 4.8111 mL | |
| 20 mM | 0.1443 mL | 0.7217 mL | 1.4433 mL | 3.6083 mL | |
| 25 mM | 0.1155 mL | 0.5773 mL | 1.1547 mL | 2.8867 mL | |
| 30 mM | 0.0962 mL | 0.4811 mL | 0.9622 mL | 2.4056 mL | |
| 40 mM | 0.0722 mL | 0.3608 mL | 0.7217 mL | 1.8042 mL | |
| 50 mM | 0.0577 mL | 0.2887 mL | 0.5773 mL | 1.4433 mL | |
| 60 mM | 0.0481 mL | 0.2406 mL | 0.4811 mL | 1.2028 mL | |
| 80 mM | 0.0361 mL | 0.1804 mL | 0.3608 mL | 0.9021 mL | |
| 100 mM | 0.0289 mL | 0.1443 mL | 0.2887 mL | 0.7217 mL |
Isorosmanol Related Classifications
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