NBI-34041
NBI-34041 (SB-723620) is a selective and orally active nonpeptide CRF1 receptor antagonist with an IC50 of 58.9 nM and a Ki of 4.0 nM for human CRF1 receptor. NBI-34041 has no inhibitory effect on the CRF2 receptor. NBI-34041 can be used for depression and anxiety disorders research.
For research use only. We do not sell to patients.
- CAS No.: 268545-87-5
- Formula: C22H26Cl2N4
- Molecular Weight:417.37
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
-
HY-14127
R121919CRF1 Receptor Antagonist -
HY-103377
Antalarmin hydrochlorideCRHR1 Antagonist -
HY-P1295
Urocortin, humanCRF Receptor Agonist -
HY-12129
CP 154526 hydrochlorideCRF1 Antagonist -
HY-135542
NBI-27914CRFR1 Antagonist -
HY-P0257
AstressinCRF Antagonist -
HY-14130
CP 376395CRF1 Receptor Antagonist -
HY-P1296
Urocortin, ratCRFR Agonist -
HY-P1106
K41498CRF2 receptor Antagonist -
HY-14875
VerucerfontCRFR Antagonist -
HY-P1107
Antisauvagine-30CRF2 Receptor Antagonist -
HY-103378
NBI 35965 methanesulfonateCRF1 Antagonist
Biological Activity
Description
IC50 & Target
[1]|
CRFR1 58.9 nM (IC50) |
CRFR1 4 nM (Ki) |
CRFR2 >10000 nM (IC50) |
In Vitro
NBI-34041 could inhibit the production of cAMP in a concentration-dependent manner with an IC50 of approximately 60 nM. At concentrations of NBI-34041 up to 10 000 nM, NBI-34041 is unable to fully inhibit sauvagine stimulated cAMP from cells expressing the human CRF2 receptor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Wistar or Sprague-Dawley rats (300-350 g)[1]
-
Dosage:3 mg/kg, 10 mg/kg, or 30 mg/kg
-
Administration:Oral gavage; a single dose
-
Result:Did not impair diurnal adrenocorticotropic hormone (ACTH) and cortisol secretion or CRF evoked ACTH and cortisol responses but attenuated the neuroendocrine response to psychosocial stress.
Chemical Information
-
CAS No. 268545-87-5
-
Molecular Weight 417.37
-
Formula C22H26Cl2N4
-
SMILES
CC1=NC2=C3C(N(C(CCC)CCC)CCN3N=C2C4=CC=C(Cl)C=C4Cl)=C1
-
Synonyms
SB-723620
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NBI-34041 Related Classifications
HY-14128 Related Classifications
Powered by Bioz