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Cat. No.: HY-P10978

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NK224

Name: NK224
Brand: MedChemExpress
SKU: HY-P10978
Price: 410.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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NK224 is a peptide-based radiotracer targeting human PD-L1, with dual-radionuclide (68Ga and 18F) labeling compatibility enabled by the NOTA chelator. NK224 exhibits high binding affinity to PD-L1, with an IC₅₀ value of 2.45 nM. NK224 visualizes tumor heterogeneity and dynamically monitors PD-L1 target occupancy during immunotherapy. NK224 can be used for the study of non-small cell lung cancer (NSCLC).

For research use only. We do not sell to patients.

Purity : 99.03%
CAS No.: 3137461-57-2
Formula: C₁₀₄H₁₄₅N₂₅O₂₉S
Molecular Weight:2241.48

Storage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

NK224 Chemical Structure

CAS No.: 3137461-57-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 3137461-57-2
Appearance Solid
Molecular Weight 2241.48
Formula C₁₀₄H₁₄₅N₂₅O₂₉S
Color White to off-white
Sequence

Cyclo(Ac-Tyr-NMeAla-Asn-Pro-His-Glu-{Hyp}-Trp-Ser-Trp(CH2COOH)-NMeNle-NMeNle-Lys(NOTA)-Cys)-Gly-NH2
Sequence Shortening

cyclo-{Ac-Y-{NMeAla}-NPHE-{Hyp}-WS-{TrpCH2COOH}-{NMeNle-NMeNle}-K(NOTA)-CG-NH2
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (296 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao L, et al. 68Ga-NK224 PET/CT for Noninvasive Evaluation of PD-L1 Expression and Intertumor Heterogeneity: A Translational Exploratory Study. Clin Cancer Res. 2025 Jul 15;31(14):2989-3001. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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