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Cat. No.: HY-164506

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NRMA-8

NRMA-8 is a brain-penetrant small molecule nuclear receptor modulator. NRMA-8 is promising for research of central nervous system disorders, including Alzheimer's disease, Parkinson's disease, demylenation disorders and glioblastomas.

For research use only. We do not sell to patients.

CAS No.: 2375659-15-5
Formula: C₂₀H₂₃ClN₂O₃
Molecular Weight:374.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

NRMA-8 Chemical Structure

CAS No.: 2375659-15-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 2375659-15-5
Molecular Weight 374.86
Formula C₂₀H₂₃ClN₂O₃
SMILES

O=C(C1=CC=C(C=C1)Cl)NCCC2=CC=C(C=C2)OC(C)(C)C(NC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. SCANLAN Thomas S, et al. N-methyl amide prodrugs of small molecule nuclear receptor modulators. WO2019168842. 2018 March 02.

[2]. Ferrara SJ, et al. A CNS-Targeting Prodrug Strategy for Nuclear Receptor Modulators. J Med Chem. 2020 Sep 10;63(17):9742-9751. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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