Perfluorodecalin
Based on 1 Customer Validation
Perfluorodecalin liquids are largrly used in vitreoretinal surgery. Perfluorodecalin with tamponade lasting more than two days is detrimental to the retina in the case of rabbit. Perfluorodecalin can be used for the research of giant retinal tears. Perfluorodecalin is a non-toxic, non-flammable, thermally stable, non-bio-accumulating O2-carrier and used as artificial blood. Perfluorodecalin enhances bone regeneration and cell viability.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 306-94-5
- Formula: C10F18
- Molecular Weight:462.08
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Perfluorodecalin prolongs the cells survival in anaerobic environment, enhances the radiopacity, injectability, cohesion of bone cements and the bone regeneration[4]. Perfluorodecalin (10% v/v) ameliorates hypoxia and increases cell viability in transplantation of encapsulated islets[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Albino rabbits[2]
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Dosage:1.1-1.5 ml for each eye
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Administration:injection into vitreous cavity
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Result:Induced appearance of foam cells, preretinal membranes, and the interface necrosis.
Chemical Information
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CAS No. 306-94-5
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Appearance Liquid (Density: 1.9456 g/cm3)
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Molecular Weight 462.08
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Formula C10F18
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Color Colorless to light yellow
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SMILES
FC12C(F)(F)C(F)(F)C(F)(F)C(F)(F)C1(F)C(F)(F)C(F)(F)C(F)(F)C2(F)F
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Synonyms
PP 5; Perfluorodecahydronaphthalene
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 66.67 mg/mL (144.28 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (466 KB)
- English - EN (466 KB)
- Français - FR (466 KB)
- Deutsch - DE (466 KB)
- Norwegian - NO (466 KB)
- Español - ES (466 KB)
- Swedish - SV (466 KB)
- Italian - IT (466 KB)
- Korean - KR (466 KB)
- Portuguese - PT (466 KB)
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Handling Instructions (2659 KB)
References
[1]. Orzalesi N, et al. Experimental short-term tolerance to perfluorodecalin in the rabbit eye: a histopathological study. Curr Eye Res. 1998;17(8):828-835. [Content Brief]
[2]. Bourke RD, et al. Experimental long-term vitreous replacement with purified and nonpurified perfluorodecalin. Am J Ophthalmol. 1994;118(3):403-404. [Content Brief]
[3]. Spahn DR. Blood substitutes. Artificial oxygen carriers: perfluorocarbon emulsions. Crit Care. 1999;3(5):R93-7. [Content Brief]
[4]. Tamimi F, et al., Perfluorodecalin and bone regeneration. Eur Cell Mater. 2013 Jan 2;25:22-36. [Content Brief]
[5]. Rodriguez-Brotons A, et al., Comparison of Perfluorodecalin and HEMOXCell as Oxygen Carriers for Islet Oxygenation in an In Vitro Model of Encapsulation. Tissue Eng Part A. 2016 Dec;22(23-24):1327-1336. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1641 mL | 10.8206 mL | 21.6413 mL | 54.1032 mL |
| 5 mM | 0.4328 mL | 2.1641 mL | 4.3283 mL | 10.8206 mL | |
| 10 mM | 0.2164 mL | 1.0821 mL | 2.1641 mL | 5.4103 mL | |
| 15 mM | 0.1443 mL | 0.7214 mL | 1.4428 mL | 3.6069 mL | |
| 20 mM | 0.1082 mL | 0.5410 mL | 1.0821 mL | 2.7052 mL | |
| 25 mM | 0.0866 mL | 0.4328 mL | 0.8657 mL | 2.1641 mL | |
| 30 mM | 0.0721 mL | 0.3607 mL | 0.7214 mL | 1.8034 mL | |
| 40 mM | 0.0541 mL | 0.2705 mL | 0.5410 mL | 1.3526 mL | |
| 50 mM | 0.0433 mL | 0.2164 mL | 0.4328 mL | 1.0821 mL | |
| 60 mM | 0.0361 mL | 0.1803 mL | 0.3607 mL | 0.9017 mL | |
| 80 mM | 0.0271 mL | 0.1353 mL | 0.2705 mL | 0.6763 mL | |
| 100 mM | 0.0216 mL | 0.1082 mL | 0.2164 mL | 0.5410 mL |
Perfluorodecalin Related Classifications
HY-108298 Related Classifications
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