UCI-1014
Based on 1 Customer Validation
UCI-1014 is a mutant p53 (p53R175H) corrector/reactivator. UCI-1014 restores the wild-type-like DNA-binding activity of p53R175H, promotes the redistribution of the mutant protein to chromatin, and induces the expression of p53-dependent target genes. UCI-1014 inhibits the proliferation of p53R175H-mutant cancer cells through an SLC7A11-independent mechanism. UCI-1014 can be used for research related to p53-mutant cancers.
For research use only. We do not sell to patients.
- Purity: 98.43%
- CAS No.: 304896-41-1
- Formula: C16H12N2O4
- Molecular Weight:296.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
UCI-1014 (72 h) inhibits the proliferation of TOV-112D cells carrying p53R175H with an IC50 of 4.5 μM[1].
UCI-1014 (10-30 μM; 3 h) restores the DNA-binding ability of p53R175H in TOV-112D cells, and evidence shows that this mutant protein redistributes to the chromatin fraction after treatment with 10 μM or 30 μM for 3 hours[1].
UCI-1014 (3 h) induces p53-dependent gene expression in TOV-112D cells, with a transcriptome profile highly similar to that of UCI-1001, and it induces a greater number of p53-dependent genes after 3 hours of treatment[1].
UCI-1014 (5-20 μM; 72 h) exhibits growth inhibitory activity against TOV-112D cells, and this activity can only be partially reversed by 5 mM N-acetylcysteine (HY-B0215), indicating that its mechanism of action differs from that of thiol-reactive compounds such as APR-246 (HY-19980)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:TOV-112D (p53-R175H)
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Concentration:5 μM, 10 μM, 20 μM
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Incubation Time:72 h
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Result:Had growth-inhibitory effects that were partially alleviated by 5 mM N-acetylcysteine at lower concentrations, but this mitigation diminished at 20 μM.
Chemical Information
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CAS No. 304896-41-1
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Appearance Solid
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Molecular Weight 296.28
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Formula C16H12N2O4
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Color Orange to red
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SMILES
CC1=CC=C(C=C1)C2=CC=C(O2)/C=C3C(NC(NC\3=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : 5.83 mg/mL (19.68 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3752 mL | 16.8759 mL | 33.7519 mL | 84.3796 mL |
| 5 mM | 0.6750 mL | 3.3752 mL | 6.7504 mL | 16.8759 mL | |
| 10 mM | 0.3375 mL | 1.6876 mL | 3.3752 mL | 8.4380 mL | |
| 15 mM | 0.2250 mL | 1.1251 mL | 2.2501 mL | 5.6253 mL |
UCI-1014 Related Classifications
HY-183622 Related Classifications
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