2. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Decylubiquinone

Decylubiquinone 

Cat. No.: HY-121134 Purity: ≥99.0%
COA Handling Instructions

Decylubiquinone is an analog of ubiquinone (coenzyme Q10). Decylubiquinone blocks reactive oxygen species (ROS) production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition.

For research use only. We do not sell to patients.

Decylubiquinone Chemical Structure

Decylubiquinone Chemical Structure

CAS No. : 55486-00-5

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Solution
5 mg (7.753 mM * 2 mL in Ethanol) USD 200 In-stock
Estimated Time of Arrival: December 31
Solution
10 mg (15.506 mM * 2 mL in Ethanol) USD 320 In-stock
Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

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Description

Decylubiquinone is an analog of ubiquinone (coenzyme Q10). Decylubiquinone blocks reactive oxygen species (ROS) production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition[1].

In Vitro

Decylubiquinone (dUb; 10 μm for 6 hours) exerts its effects on ROS by either inhibition of ROS production by cytochrome bc1 or that it scavenged ROS produced[1].
Decylubiquinone inhibits both the dichlorofluorescein (DCF) fluorescence increase resulting from H2O2 treatment and the DCF fluorescence increase resulting after glutathione (GSH) depletion using diethylmaleate mitochondrially generated ROS)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HL60 cells transfected with bcl-2 (bcl-2) (HL60 B cells)
Concentration: 10 μM
Incubation Time: 6 hours
Result: Attenuated the ROS increase in HL60 (B) cells.
Molecular Weight

322.44

Appearance

Liquid

Formula

C19H30O4
CAS No.
SMILES

O=C1C(CCCCCCCCCC)=C(C(C(OC)=C1OC)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: ≥99.0%

COA (242 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Decylubiquinone55486-00-5Reactive Oxygen SpeciesUbiquinonecoenzyme Q10reactiveoxygenspeciesROSproductionglutathionedepletionmitochondrialpermeabilitytransitionInhibitorinhibitorinhibit

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