Decylubiquinone

Name: Decylubiquinone
Brand: MedChemExpress
SKU: HY-121134
Rating: 4.5 (1 reviews)

Cat. No.: HY-121134 Purity: 99.67%: Data Sheet
COA

SDS
Handling Instructions
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Decylubiquinone is an analog of ubiquinone (coenzyme Q₁₀). Decylubiquinone blocks reactive oxygen species (ROS) production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition.

For research use only. We do not sell to patients.

Decylubiquinone Chemical Structure

CAS No. : 55486-00-5

Size	Stock	Quantity
Solvent
5 mg (77.53 mM * 200 μL in Ethanol)	In-stock	Estimated Time of Arrival: December 31
Solvent
10 mg (77.53 mM * 400 μL in Ethanol)	In-stock	Estimated Time of Arrival: December 31

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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Decylubiquinone

•Acta Pharmacol Sin. 2025 Jun 23. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Decylubiquinone (dUb; 10 μm for 6 hours) exerts its effects on ROS by either inhibition of ROS production by cytochrome bc1 or that it scavenged ROS produced^[1].
Decylubiquinone inhibits both the dichlorofluorescein (DCF) fluorescence increase resulting from H₂O₂ treatment and the DCF fluorescence increase resulting after glutathione (GSH) depletion using diethylmaleate mitochondrially generated ROS)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	HL60 cells transfected with bcl-2 (bcl-2) (HL60 B cells)
Concentration:	10 μM
Incubation Time:	6 hours
Result:	Attenuated the ROS increase in HL60 (B) cells.

Molecular Weight

322.44

Formula

C₁₉H₃₀O₄

CAS No.

55486-00-5

Appearance

Liquid

Color

Yellow to brown

SMILES

O=C1C(CCCCCCCCCC)=C(C(C(OC)=C1OC)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (310.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.67%

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Data Sheet (268 KB) SDS (393 KB)

COA (242 KB) HNMR (338 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Jeffrey S Armstrong, et al. The Coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: role of mitcohondrial [correction mitochondrial] complex III. J Biol Chem. 2003 Dec 5;278(49):49079-84. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1014 mL	15.5068 mL	31.0135 mL	77.5338 mL
	5 mM	0.6203 mL	3.1014 mL	6.2027 mL	15.5068 mL
	10 mM	0.3101 mL	1.5507 mL	3.1014 mL	7.7534 mL
	15 mM	0.2068 mL	1.0338 mL	2.0676 mL	5.1689 mL
	20 mM	0.1551 mL	0.7753 mL	1.5507 mL	3.8767 mL
	25 mM	0.1241 mL	0.6203 mL	1.2405 mL	3.1014 mL
	30 mM	0.1034 mL	0.5169 mL	1.0338 mL	2.5845 mL
	40 mM	0.0775 mL	0.3877 mL	0.7753 mL	1.9383 mL
	50 mM	0.0620 mL	0.3101 mL	0.6203 mL	1.5507 mL
	60 mM	0.0517 mL	0.2584 mL	0.5169 mL	1.2922 mL
	80 mM	0.0388 mL	0.1938 mL	0.3877 mL	0.9692 mL
	100 mM	0.0310 mL	0.1551 mL	0.3101 mL	0.7753 mL