2. PROTAC
  3. Ligands for E3 Ligase
  4. Deoxy-thalidomide-OMe

Deoxy-thalidomide-OMe is an E3 ligase ligand. Deoxy-thalidomide-OMe can be used for synthesis of PROTAC LRRK2 Degrader-4 (HY-178796).

For research use only. We do not sell to patients.

Deoxy-thalidomide-OMe

Deoxy-thalidomide-OMe Chemical Structure

CAS No. : 1061605-49-9

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Deoxy-thalidomide-OMe Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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  • Purity & Documentation

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  • Customer Review

Description

Deoxy-thalidomide-OMe is an E3 ligase ligand. Deoxy-thalidomide-OMe can be used for synthesis of PROTAC LRRK2 Degrader-4 (HY-178796)[1].

Cellular Effect
Cell Line Type Value Description References
NAMALVA IC50
> 1 μM
Compound: 19
Antiproliferative activity against human NAMALWA cells assessed as inhibition of [3H]thymidine incorporation after 72 hrs by scintillation counting
Antiproliferative activity against human NAMALWA cells assessed as inhibition of [3H]thymidine incorporation after 72 hrs by scintillation counting
[PMID: 23168019]
PBMC IC50
1.2 μM
Compound: 19
Inhibition of TNF-alpha production in LPS-stimulated human PBMC preincubated for 1 hr before LPS challenge measured after 28 to 20 hrs by ELISA
Inhibition of TNF-alpha production in LPS-stimulated human PBMC preincubated for 1 hr before LPS challenge measured after 28 to 20 hrs by ELISA
[PMID: 23168019]
T-cell EC50
0.65 μM
Compound: 19
Inhibition of IL-2 production in human T cells measured after 2 to 3 days by ELISA
Inhibition of IL-2 production in human T cells measured after 2 to 3 days by ELISA
[PMID: 23168019]
Molecular Weight

274.27

Formula

C14H14N2O4
CAS No.
SMILES

COC1=CC=CC2=C1CN(C2=O)C3CCC(NC3=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Deoxy-thalidomide-OMe Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deoxy-thalidomide-OMe1061605-49-9Ligands for E3 LigaseE3 ligase-recruiting MoietyPROTACInhibitorinhibitorinhibit

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Deoxy-thalidomide-OMe
Cat. No.:
HY-179222
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