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Cat. No.: HY-100404R

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DFMTI (Standard)

Name: DFMTI (Standard)
Brand: MedChemExpress
SKU: HY-100404R
Availability: PreOrder

(Synonyms: MK5435 (Standard))

DFMTI (Standard) (MK5435 (Standard)) is the analytical standard of DFMTI (HY-100404). This product is intended for research and analytical applications. DFMTI is a blood-brain barrier-penetrant mGluR1 inhibitor. DFMTI abolishes the tobacco mosaic virus (TMV) resistance phenotype of NbAS-B-overexpressing plants by inhibiting glutamate production required for the activation of the Salicylic acid (HY-B0167) pathway. DFMTI disrupts prepulse inhibition in rats. DFMTI can be used in research related to psychiatric disorders and tobacco mosaic virus infection.

For research use only. We do not sell to patients.

CAS No.: 864864-86-8
Formula: C₂₀H₁₈F₂N₄O
Molecular Weight:368.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DFMTI (Standard) Chemical Structure

CAS No.: 864864-86-8

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 864864-86-8
Molecular Weight 368.38
Formula C₂₀H₁₈F₂N₄O
SMILES

O=C(N(C(C)C)C1)C2=C1C=C(C3=C(C)N(C4=CC=C(F)C=C4F)N=N3)C=C2
Synonyms

MK5435 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Qiao G, et al. The Multifaceted Functions of Plant Asparagine Synthetase: Regulatory Mechanisms and Functional Diversity in Growth and Defense. Plants (Basel, Switzerland). 2026 Jan 24;15(3):362.

[2]. Hostetler ED, et al. Synthesis, characterization, and monkey PET studies of [¹⁸F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435. Synapse (New York, N.Y.). 2011 Feb;65(2):125-35. [Content Brief]

[3]. Cho HP, et al. A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors. ACS chemical neuroscience. 2014 Jul 16;5(7):597-610. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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