2. PROTAC
  3. Molecular Glues
  4. DHC-286

DHC-286 is a molecular glue degrader targeting GSPT1. DHC-286 recruits GSPT1 to the CRL4CRBN ubiquitin ligase complex, promoting GSPT1 ubiquitination and proteasomal degradation, inducing cytotoxicity. DHC-286 is promising for research of cancers such as acute myeloid leukemia.

For research use only. We do not sell to patients.

DHC-286

DHC-286 Chemical Structure

CAS No. : 2920443-08-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

DHC-286 Related Antibodies

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Description

DHC-286 is a molecular glue degrader targeting GSPT1. DHC-286 recruits GSPT1 to the CRL4CRBN ubiquitin ligase complex, promoting GSPT1 ubiquitination and proteasomal degradation, inducing cytotoxicity. DHC-286 is promising for research of cancers such as acute myeloid leukemia[1].

Molecular Weight

475.42

Formula

C23H20F3N3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1=CC=CC=C1C(F)(F)F)COC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3)=O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (52.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1034 mL 10.5170 mL 21.0340 mL
5 mM 0.4207 mL 2.1034 mL 4.2068 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1034 mL 10.5170 mL 21.0340 mL 52.5851 mL
5 mM 0.4207 mL 2.1034 mL 4.2068 mL 10.5170 mL
10 mM 0.2103 mL 1.0517 mL 2.1034 mL 5.2585 mL
15 mM 0.1402 mL 0.7011 mL 1.4023 mL 3.5057 mL
20 mM 0.1052 mL 0.5259 mL 1.0517 mL 2.6293 mL
25 mM 0.0841 mL 0.4207 mL 0.8414 mL 2.1034 mL
30 mM 0.0701 mL 0.3506 mL 0.7011 mL 1.7528 mL
40 mM 0.0526 mL 0.2629 mL 0.5259 mL 1.3146 mL
50 mM 0.0421 mL 0.2103 mL 0.4207 mL 1.0517 mL
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DHC-286 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHC-2862920443-08-7DHC286DHC 286Molecular Gluesmolecular glueGSPT1cytotoxicityInhibitorinhibitorinhibit

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