DHC-286
Based on 1 Customer Validation
DHC-286 is a molecular glue degrader targeting GSPT1. DHC-286 recruits GSPT1 to the CRL4CRBN ubiquitin ligase complex, promoting GSPT1 ubiquitination and proteasomal degradation, inducing cytotoxicity. DHC-286 is promising for research of cancers such as acute myeloid leukemia.
For research use only. We do not sell to patients.
- Purity: 98.00%
- CAS No.: 2920443-08-7
- Formula: C23H20F3N3O5
- Molecular Weight:475.42
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 2920443-08-7
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Appearance Solid
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Molecular Weight 475.42
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Formula C23H20F3N3O5
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Color White to off-white
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SMILES
O=C(NCC1=CC=CC=C1C(F)(F)F)COC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3)=O)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (52.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1034 mL | 10.5170 mL | 21.0340 mL | 52.5851 mL |
| 5 mM | 0.4207 mL | 2.1034 mL | 4.2068 mL | 10.5170 mL | |
| 10 mM | 0.2103 mL | 1.0517 mL | 2.1034 mL | 5.2585 mL | |
| 15 mM | 0.1402 mL | 0.7011 mL | 1.4023 mL | 3.5057 mL | |
| 20 mM | 0.1052 mL | 0.5259 mL | 1.0517 mL | 2.6293 mL | |
| 25 mM | 0.0841 mL | 0.4207 mL | 0.8414 mL | 2.1034 mL | |
| 30 mM | 0.0701 mL | 0.3506 mL | 0.7011 mL | 1.7528 mL | |
| 40 mM | 0.0526 mL | 0.2629 mL | 0.5259 mL | 1.3146 mL | |
| 50 mM | 0.0421 mL | 0.2103 mL | 0.4207 mL | 1.0517 mL |
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