1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Dihydroorotate Dehydrogenase
    DNA/RNA Synthesis
  3. DHODH-IN-11

DHODH-IN-11 

Cat. No.: HY-135675
Handling Instructions

DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.

For research use only. We do not sell to patients.

DHODH-IN-11 Chemical Structure

DHODH-IN-11 Chemical Structure

CAS No. : 1263303-95-2

Size Price Stock Quantity
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
25 mg USD 380 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03[1].

IC50 & Target

pKa: 5.03 (DHODH)[1]

In Vitro

Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 14a), is designed. Compound 14a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-11 (Compound 14b). DHODH-IN-14 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

265.27

Formula

C₁₅H₁₁N₃O₂

CAS No.

1263303-95-2

SMILES

O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)/C(C#N)=N/O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (471.22 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7697 mL 18.8487 mL 37.6974 mL
5 mM 0.7539 mL 3.7697 mL 7.5395 mL
10 mM 0.3770 mL 1.8849 mL 3.7697 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (7.84 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

DHODH-IN-11Dihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHRatLeflunomideantiinflammatorycyano-oximesInhibitorinhibitorinhibit

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Product Name:
DHODH-IN-11
Cat. No.:
HY-135675
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