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Cat. No.: HY-14142

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AP-24226

AP-24226 is a potent inhibitor of Scr/ABL.

For research use only. We do not sell to patients.

CAS No.: 926922-22-7
Formula: C₂₄H₂₀F₃N₇O
Molecular Weight:479.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

AP-24226 Chemical Structure

CAS No.: 926922-22-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

AP-24226 is a potent inhibitor of Scr/ABL^[1].

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	2746 nM Compound: 9i, AP24226	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	2746 nM Compound: Id	Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	4.8 nM Compound: Id	Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	4.8 μM Compound: 9i, AP24226	Antiproliferative activity against mouse BA/F3 cells expressing wild type Bcr-Abl after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing wild type Bcr-Abl after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	4894 μM Compound: 9i, AP24226	Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay	[PMID: 19572547]
K562	IC₅₀	6.1 μM Compound: 9i, AP24226	Antiproliferative activity against human K562 cells after 3 days by MTS assay Antiproliferative activity against human K562 cells after 3 days by MTS assay	[PMID: 19572547]

Chemical Information

CAS No. 926922-22-7
Molecular Weight 479.46
Formula C₂₄H₂₀F₃N₇O
SMILES

O=C(NC1=NC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(/C=C/N3C=NC4=C(NC5CC5)N=CN=C34)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang, W. S., et al., (2009). 9-(Arenethenyl)purines as Dual Src/Abl Kinase Inhibitors Targeting the Inactive Conformation: J. Med. Chem., 2009, 52 (15), pp 4743-4756 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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AP-24226

All Bcr-Abl Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AP-24226 Related Classifications

HY-14142 Related Classifications