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Cat. No.: HY-119613

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Clociguanil

(Synonyms: BRL 50216)

Clociguanil (BRL 50216), a DHFR inhibitor (IC₅₀: 55.6 nM), is an antimalarial agent. Clociguanil has sympathomimetic and antiarrhythmic action.

For research use only. We do not sell to patients.

CAS No.: 3378-93-6
Formula: C₁₂H₁₅Cl₂N₅O
Molecular Weight:316.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Clociguanil Chemical Structure

CAS No.: 3378-93-6

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Biological Activity

Description

Clociguanil (BRL 50216), a DHFR inhibitor (IC₅₀: 55.6 nM), is an antimalarial agent. Clociguanil has sympathomimetic and antiarrhythmic action^[1]^[2].

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Chemical Information

CAS No. 3378-93-6
Molecular Weight 316.19
Formula C₁₂H₁₅Cl₂N₅O
SMILES

NC1=NC(N)=NC(C)(N1OCC2=CC=C(C(Cl)=C2)Cl)C
Synonyms

BRL 50216
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nettleton MJ, et al. The cardiovascular effects of two new triazine antimalarials, BRL 50216 (Clociguanil) and BRL 6231. Toxicol Appl Pharmacol. 1974 Feb;27(2):271-82. [Content Brief]

[2]. Winstanley PA, et al. In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39(4):948-52. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Clociguanil

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Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Clociguanil Related Classifications

HY-119613 Related Classifications