HNRNPR - heterogeneous nuclear ribonucleoprotein R Gene

Also Known as HNRPR; NEDDFSB; hnRNP-R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10236

About HNRNPR

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,304,688-23,344,284 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 236 orthologues, 24 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 17.7), appendix (RPKM 17.6) and 25 other tissues.

Summary

This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-Fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]

HNRNPR Products (7)

mRNA Protein Name
NM_001102397.3 NP_001095867.1 heterogeneous nuclear ribonucleoprotein R isoform 4
NM_001102398.3 NP_001095868.1 heterogeneous nuclear ribonucleoprotein R isoform 1
NM_001102399.3 NP_001095869.1 heterogeneous nuclear ribonucleoprotein R isoform 3
NM_001297620.2 NP_001284549.1 heterogeneous nuclear ribonucleoprotein R isoform 5
NM_001297621.2 NP_001284550.1 heterogeneous nuclear ribonucleoprotein R isoform 7
NM_001297622.2 NP_001284551.1 heterogeneous nuclear ribonucleoprotein R isoform 6
NM_005826.5 NP_005817.1 heterogeneous nuclear ribonucleoprotein R isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
Cellular Component GO Annotation Evidence References Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
NOT located in nucleolus IDA
IDA: Inferred from direct assay
9421497 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
9421497 GOA
located in nucleus IDA
IDA: Inferred from direct assay
31079900 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
17289661 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPR Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (167 - 231)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (248 - 309)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (343 - 404)

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  • 633 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein R

HNRNPR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HNRNPR O43390 NCK1 Homo sapiens P16333
Peptide Array
17474147
Intra
HNRNPR O43390 KHDRBS2 Homo sapiens Q5VWX1
Y2H Prey Pooling
25416956
Intra
HNRNPR O43390 KHDRBS2 Homo sapiens Q5VWX1
Validated Y2H
25416956
Intra
HNRNPR O43390 PRMT1 Homo sapiens Q99873
Y2H Prey Pooling
25416956
Intra
HNRNPR O43390 PRMT1 Homo sapiens Q99873
Y2H Pooling
16169070
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HNRNPR Proteins

Cat. No. Product Name Accession Purity
HY-P73920 HNRNPR Protein, Human (sf9, His-GST) O43390-2 (A2-K636) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Dysmorphic Facies And Skeletal And Brain Abnormalities

  • NEDDFSB
Spinal Muscular Atrophy

  • Sma

  • 5q Sma

  • Proximal Sma

  • Sma-Associated Sma

  • Spinal Amyotrophies

  • Spinal Amyotrophy

  • Spinal Muscle Degeneration

  • Spinal Muscle Wasting

  • Muscular Atrophy Spinal

  • Atrophy, Muscular, Spinal

  • Hereditary Motor Neuronopathy

  • Progressive Muscular Atrophy

  • Sma - [Spinal Muscular Atrophy]
Muscular Atrophy

  • Muscle Wasting

  • Amyotrophia

  • Wasting - Muscle

  • Skeletal Muscle Atrophy
Spinal Muscular Atrophy, Type Iii

  • SMA3

  • Juvenile Spinal Muscular Atrophy

  • Kugelberg-Welander Disease

  • Sma Iii

  • Kugelberg-Welander Syndrome

  • Kws

  • Muscular Atrophy, Juvenile

  • Spinal Muscular Atrophy, Mild Childhood And Adolescent Form

  • Spinal Muscular Atrophy-3

  • Spinal Muscular Atrophy Type 3

  • Spinal Muscular Atrophy, Type Iii, Modifier Of

  • Type Iii Spinal Muscular Atrophy

  • Sma 3

  • Proximal Spinal Muscular Atrophy Type 3

  • Sma Type 3

  • Sma Type Iii

  • Sma-Iii

  • Spinal Muscular Atrophy 3

  • Spinal Muscular Atrophy Mild Childhood And Adolescent Form

  • Spinal Muscular Atrophy Type Iii

  • Wohlfart-Kugelberg-Welander Disease

  • Atrophy, Muscular, Spinal, Type Iii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06277 HNRNPR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20164 Hnrnpr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26668 Hnrnpr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HNRNPR RGD RGD:631348
Felis catus HNRNPR VGNC VGNC:67612
Mus musculus HNRNPR MGD MGI:1891692
Canis familiaris HNRNPR VGNC VGNC:41735
Bos taurus HNRNPR VGNC VGNC:29899
Macaca mulatta HNRNPR VGNC VGNC:73499
Others HNRNPR NCBI