PLRG1 - pleiotropic regulator 1 Gene

Also Known as Cwc1; PRL1; PRP46; PRPF46; TANGO4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5356

About PLRG1

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:154,535,005-154,550,400 (from NCBI)

This gene has 13 transcripts (splice variants) and 219 orthologues. Ubiquitous expression in thyroid (RPKM 15.5), brain (RPKM 13.3) and 25 other tissues.

Summary

This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

PLRG1 Products (2)

mRNA Protein Name
NM_001201564.2 NP_001188493.1 pleiotropic regulator 1 isoform 2
NM_002669.4 NP_002660.1 pleiotropic regulator 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17332742 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
Cellular Component GO Annotation Evidence References Source
part of DNA replication factor A complex IDA
IDA: Inferred from direct assay
24332808 GOA
part of Prp19 complex IPI
IPI: Inferred from physical interaction
20176811 GOA
part of U2-type catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28076346 GOA
part of spliceosomal complex IPI
IPI: Inferred from physical interaction
20176811 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLRG1 Protein Structure

WD40

WD40: WD domain, G-beta repeat (194 - 232)

WD40

WD40: WD domain, G-beta repeat (236 - 274)

WD40

WD40: WD domain, G-beta repeat (279 - 316)

WD40

WD40: WD domain, G-beta repeat (323 - 358)

WD40

WD40: WD domain, G-beta repeat (365 - 398)

WD40

WD40: WD domain, G-beta repeat (405 - 440)

WD40

WD40: WD domain, G-beta repeat (462 - 489)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 514 a.a.
Protein Preferred Names Protein Names

pleiotropic regulator 1

  • pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)

PLRG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLRG1 O43660 BCAS2 Homo sapiens O75934
Anti Bait CoIP
17353931
Intra
PLRG1 O43660 BCAS2 Homo sapiens O75934
Crosslink
20176811
Intra
PLRG1 O43660 BCAS2 Homo sapiens O75934
Anti Tag CoIP
33961781
Intra
PLRG1 O43660 SF3A2 Homo sapiens Q15428
Affinity Chrom
17332742
Intra
PLRG1 O43660 CDC5L Homo sapiens Q99459
Anti Tag CoIP
33961781
Intra
PLRG1 O43660 CDC5L Homo sapiens Q99459
Anti Bait CoIP
17353931
Intra
PLRG1 O43660 CDC5L Homo sapiens Q99459
Far-WB
20176811
Intra
PLRG1 O43660 PRPF19 Homo sapiens Q9UMS4
Crosslink
20176811
Intra
PLRG1 O43660 PRPF19 Homo sapiens Q9UMS4
Anti Bait CoIP
17353931
Intra
PLRG1 O43660 PRPF19 Homo sapiens Q9UMS4
Anti Tag CoIP
33961781
Intra
PLRG1 O43660 HNRNPM Homo sapiens P52272
IF
20467437
Intra
PLRG1 O43660 HNRNPM Homo sapiens P52272
Anti Bait CoIP
20467437
Intra
PLRG1 O43660 HNRNPM Homo sapiens P52272
Pull Down
20467437
Intra
PLRG1 O43660 HNRNPM Homo sapiens P52272
FRET
20467437
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Poikiloderma With Neutropenia

  • Poikiloderma With Neutropenia, Clericuzio Type

  • PN

  • Clericuzio Type Poikiloderma With Neutropenia

  • Poikiloderma With Neutropenia, Clericuzio-Type

  • Clericuzio-Type Poikiloderma With Neutropenia

  • Poikiloderma With Neutropenia Clericuzio Type

  • Immune-Deficient Poikiloderma

  • Clericuzio-Type Poikiloderma Neutropenia Syndrome

  • Poikiloderma With Neutropenia Clericuzio-Type

  • Poikiloderma, With Neutropenia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10738 PLRG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PLRG1 MGD MGI:1858197
Rattus norvegicus PLRG1 RGD RGD:621047
Bos taurus PLRG1 VGNC VGNC:33050
Macaca mulatta PLRG1 VGNC VGNC:76180
Canis familiaris PLRG1 VGNC VGNC:44710
Felis catus PLRG1 VGNC VGNC:68911
Others PLRG1 NCBI