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KAT2B - lysine acetyltransferase 2B Gene

Also Known as CAF; PCAF; P/CAF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8850

About KAT2B

Cytogenetic location: 3p24.3 Genomic coordinates (GRCh38): 3:20,040,446-20,154,404 (from NCBI)

This gene has 5 transcripts (splice variants), 219 orthologues and 11 paralogues. Ubiquitous expression in brain (RPKM 17.7), bone marrow (RPKM 16.3) and 25 other tissues.

Summary

CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-Jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]

KAT2B Products (3)

mRNA	Protein	Name
XM_005265528.5	XP_005265585.1	histone acetyltransferase KAT2B isoform X1
NM_003884.5	NP_003875.3	histone acetyltransferase KAT2B
XM_047449147.1	XP_047305103.1	histone acetyltransferase KAT2B isoform X2

KAT2B Protein Structure

PCAF_N

Acetyltransf_7

Bromodomain

0
200
400
600
832 a.a.

Protein Preferred Names	Protein Names
histone acetyltransferase KAT2B	CREBBP-associated factor K(lysine) acetyltransferase 2B histone acetylase PCAF histone acetyltransferase PCAF p300/CBP-associated factor spermidine acetyltransferase KAT2B

KAT2B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KAT2B	Q92831	BUB1B	Homo sapiens	O60566	Enzymatic Study	19407811
Intra	KAT2B	Q92831	BUB1B	Homo sapiens	O60566	Anti Tag CoIP	19407811
Intra	KAT2B	Q92831	BUB1B	Homo sapiens	O60566	Anti Tag CoIP	24825348
Intra	KAT2B	Q92831	TWIST1	Homo sapiens	Q15672	Anti Tag CoIP	18504427
Intra	KAT2B	Q92831	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	19188449
Cross	KAT2B	Q92831	Tp63	Mus musculus	O88898-2	Acetylase Assay	22575646
Cross	KAT2B	Q92831	N	SARS-CoV-2	P0DTC9	Acetylase Assay	33894414
Intra	KAT2B	Q92831	HIF1A	Homo sapiens	Q16665	Anti Bait CoIP	16543236
Intra	KAT2B	Q92831	HIF1A	Homo sapiens	Q16665	Pull Down	16543236
Intra	KAT2B	Q92831	SIRT2	Homo sapiens	Q8IXJ6	Pull Down	12887892
Intra	KAT2B	Q92831	SIRT2	Homo sapiens	Q8IXJ6	Anti Tag CoIP	12887892
Intra	KAT2B	Q92831	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	KAT2B	Q92831	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	KAT2B	Q92831	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	KAT2B	Q92831	TAF9	Homo sapiens	Q16594	Anti Bait CoIP	9674425
Intra	KAT2B	Q92831	EHMT2	Homo sapiens	Q96KQ7	Anti Bait CoIP	24492005
Intra	KAT2B	Q92831	EHMT2	Homo sapiens	Q96KQ7	Anti Tag CoIP	24492005
Intra	KAT2B	Q92831	CREBBP	Homo sapiens	Q92793	Pull Down	8684459
Intra	KAT2B	Q92831	CREBBP	Homo sapiens	Q92793	Anti Bait CoIP	8684459
Intra	KAT2B	Q92831	CREBBP	Homo sapiens	Q92793	Pull Down	9687513
Cross	KAT2B	Q92831	E7	Human papillomavirus	P03129	Y2H	12813456
Cross	KAT2B	Q92831	E7	Human papillomavirus	P03129	Anti Bait CoIP	12163591
Cross	KAT2B	Q92831	e1a_ade05	Human adenovirus C	P03255	Y2H	9687513
Cross	KAT2B	Q92831	e1a_ade05	Human adenovirus C	P03255	Pull Down	9687513

Cross: Cross-species interaction Intra: Intraspecies interaction

KAT2B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84706	KAT2B Antibody (YA4403)	IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P84706A	KAT2B Antibody (YA4403)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 7	Spinocerebellar Ataxia Type 7 SCA7 Opca3 Opca Iii Olivopontocerebellar Atrophy Iii Opca With Retinal Degeneration Opca With Macular Degeneration And External Ophthalmoplegia Adca, Type Ii Autosomal Dominant Cerebellar Ataxia Type 2 Olivopontocerebellar Atrophy 3 Autosomal Dominant Cerebellar Ataxia, Type Ii Autosomal Dominant Cerebellar Ataxia Type Ii Adca2 Adcaii Ataxia With Pigmentary Retinopathy Cerebellar Syndrome-Pigmentary Maculopathy Syndrome Olivopontocerebellar Atrophy With Retinal Degeneration Spinocerebellar Ataxia-7 Ataxia, Spinocerebellar, Type 7
Rhabdomyosarcoma
Chromosome 16p13.3 Deletion Syndrome, Proximal	Rubinstein-Taybi Syndrome Broad Thumb-Hallux Syndrome Chromosome 16p13.3 Deletion Syndrome Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion Rubinstein Syndrome Broad Thumbs-Halluces Syndrome Rsts Rubinstein-Taybi Deletion Syndrome Rsts Deletion Syndrome Proximal Chromosome 16p13.3 Deletion Syndrome 16p13.3 Deletion Syndrome Broad Thumbs And Great Toes, Characteristic Facies, And Mental Retardation Rts
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W015239	KAT8-IN-1		99.61%	Unkown
HY-173158	AUR1545	Inhibitor	99.58%	Unkown
HY-122822	GSK699		98.80%	Unkown
HY-168428	CHI-KAT8i5		98.00%	Unkown
HY-181695	PROTAC KAT2A/B degrader-1	Degrader	/	Unkown
HY-RS07077	KAT2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07078	Kat2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07079	KAT2B Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KAT2B	VGNC	VGNC:42210
Rattus norvegicus	KAT2B	RGD	RGD:1305902
Felis catus	KAT2B	VGNC	VGNC:68709
Macaca mulatta	KAT2B	VGNC	VGNC:74036
Mus musculus	KAT2B	MGD	MGI:1343094
Bos taurus	KAT2B	VGNC	VGNC:30399
Others	KAT2B	NCBI