GPCR modulator-1
GPCR modulator-1 is a negative allosteric modulator of the GLP-1 receptor (GLP-1R). GPCR modulator-1 can be used for the study of type 2 diabetes.
For research use only. We do not sell to patients.
- CAS No.: 1407592-99-7
- Formula: C26H28F3N5O3
- Molecular Weight:515.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GPCR modulator-1 (PF-06372222) can effectively inhibit the cAMP accumulation caused by GLP-1 stimulation in HEK-293T cells expressing wild-type GLP-1R. Its pIC50 value is 5.15. After mutations at C347 and I328, its efficacy is enhanced, with pIC50 values of 5.97 and 5.55, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1407592-99-7
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Molecular Weight 515.53
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Formula C26H28F3N5O3
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SMILES
O=C(O)CCNC(C1=CC=C([C@@H](C2CC(C)(C)C2)NC3=CC=C(N4C=C(C(F)(F)F)N=C4)N=C3)C=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GPCR modulator-1 Related Classifications
HY-124803 Related Classifications
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