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Cat. No.: HY-121611

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HI-236

HI-236 is a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase.? HI-236 inhibits HIV activity (wild type HTLV_IIB IC₅₀p24 < 0.001 μM).

For research use only. We do not sell to patients.

CAS No.: 233271-65-3
Formula: C₁₆H₁₈BrN₃O₂S
Molecular Weight:396.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

HI-236 Chemical Structure

CAS No.: 233271-65-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

HI-236 is a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase.? HI-236 inhibits HIV activity (wild type HTLV_IIB IC₅₀p24 < 0.001 μM)^[1].

IC₅₀ & Target

wild type HTLV_IIB IC₅₀p24 <0.001 μM)^[1]

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MT2	EC₅₀	0.042 μM Compound: HI-236	Antiviral activity against HIV1 3B in MT2 cells assessed as inhibition of viral-mediated T-cell death by MTT method Antiviral activity against HIV1 3B in MT2 cells assessed as inhibition of viral-mediated T-cell death by MTT method	[PMID: 17317163]
MT2	IC₅₀	>1 μM Compound: HI-236	Cytotoxicity against human MT2 cells Cytotoxicity against human MT2 cells	[PMID: 17317163]
MT2	CC₅₀	1 μM Compound: HI-236	Cytotoxicity against mock-infected human MT2 cells after 5 days by MTT assay Cytotoxicity against mock-infected human MT2 cells after 5 days by MTT assay	[PMID: 18996020]
MT2	EC₅₀	0.048 μM Compound: HI-236	Antiviral activity against nevirapine-resistant HIV1 3B infected in human MT2 cells assessed as inhibition of viral replication after 5 days by MTT assay Antiviral activity against nevirapine-resistant HIV1 3B infected in human MT2 cells assessed as inhibition of viral replication after 5 days by MTT assay	[PMID: 18996020]
MT2	EC₅₀	1200 nM Compound: HI-236	Antiviral activity against nevirapine-resistant HIV1 with reverse transcriptase Y181C mutation in human MT2 cells assessed as inhibition of viral replication after 5 days by MTT assay Antiviral activity against nevirapine-resistant HIV1 with reverse transcriptase Y181C mutation in human MT2 cells assessed as inhibition of viral replication after 5 days by MTT assay	[PMID: 18996020]
MT2	CC₅₀	18 μM Compound: HI-236	Cytotoxicity against HIV1 Y181C mutant infected human MT2 cells after 5 days by MTT assay Cytotoxicity against HIV1 Y181C mutant infected human MT2 cells after 5 days by MTT assay	[PMID: 18996020]
MT2	CC₅₀	>1 μM Compound: HI-236	Cytotoxicity against human MT2 cells after 5 days by MTT assay Cytotoxicity against human MT2 cells after 5 days by MTT assay	[PMID: 20605472]
MT2	EC₅₀	0.042 μM Compound: HI-236	Antiviral activity against HIV1 3B infected in human MT-2 cells assessed as inhibition of viral-mediated cell death after 5 days by MTT assay Antiviral activity against HIV1 3B infected in human MT-2 cells assessed as inhibition of viral-mediated cell death after 5 days by MTT assay	[PMID: 20605472]

Chemical Information

CAS No. 233271-65-3
Molecular Weight 396.30
Formula C₁₆H₁₈BrN₃O₂S
SMILES

S=C(NC1=NC=C(C=C1)Br)NCCC2=CC(OC)=CC=C2OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sudbeck, E. A, et al. N'-(5-bromo-2-pyridyl)- N -[2-(2,5-dimethoxyphenyl)ethyl]thiourea. Acta Crystallographica Section C Crystal Structure Communications, 55(12), 2122–2124. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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HI-236

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HI-236 Related Classifications

HY-121611 Related Classifications