CD52
CD52 is a remarkably small GPI-anchored antigen consisting of a 12-amino-acid peptide carrying a large N-linked carbohydrate, encoded by the CD52 gene. It is abundant on virtually all mature lymphocytes, monocytes, eosinophils, dendritic cells and the male reproductive tract epithelium, with particularly high density on T and B lymphocytes. Its physiological function remains incompletely defined but is thought to involve membrane organization and regulation of complement activation on lymphocytes. The monoclonal antibody alemtuzumab targets CD52 and is used to treat B cell chronic lymphocytic leukemia and relapsing-remitting multiple sclerosis, making CD52 a clinically validated depletion target.
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CD52 Recombinant Proteins (8)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
