DMG-PEG2000-A7R

DMG-PEG2000-A7R (DMG-PEG2000-Mal-Cys-ATWLPPR) is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing spatial separation between the lipid surface and the targeting ligand. 3. A7R peptide: Targeting/functional ligand-the A7R peptide (sequence ATWLPPR) binds with high affinity to neuropilin 1 (NRP-1), which is highly expressed on the surface of various tumor cells, competitively inhibiting the interaction between VEGF 165 and NRP-1, exhibiting anti-angiogenic activity.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.