2. Cell Cycle/DNA Damage
  3. Eukaryotic Initiation Factor (eIF)
  4. DNL343

DNL343 is a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that inhibits the abnormal integrated stress response (ISR). DNL343 inhibits ISR activity in the central nervous system (CNS) and reverses neurodegeneration and neuroinflammation. DNL343 also prevents motor dysfunction and premature death in eIF2B loss-of-function (LOF) mutant mice. DNL343 has inhibitory potential in studies of vanishing white matter disease (VWMD) driven by eIF2B LOF and chronic ISR activation.

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DNL343 Chemical Structure

DNL343 Chemical Structure

CAS No. : 2278265-85-1

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Description

DNL343 is a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that inhibits the abnormal integrated stress response (ISR). DNL343 inhibits ISR activity in the central nervous system (CNS) and reverses neurodegeneration and neuroinflammation. DNL343 also prevents motor dysfunction and premature death in eIF2B loss-of-function (LOF) mutant mice. DNL343 has inhibitory potential in studies of vanishing white matter disease (VWMD) driven by eIF2B LOF and chronic ISR activation[1].

IC50 & Target

eIF2B, integrated stress response (ISR)[1]
Molecular Weight

457.83

Formula

C20H19ClF3N3O4
CAS No.
SMILES

ClC(C=C1)=CC=C1OCC(NC23CC(C3)(C4=NN=C([C@@H]5C[C@@H](C5)OC(F)(F)F)O4)C2)=O
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Room temperature in continental US; may vary elsewhere.
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References
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DNL343 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNL3432278265-85-1DNL 343DNL-343Eukaryotic Initiation Factor (eIF)Brain permeabilityAbnormal integrated stress responsecentral nervous systemInhibitorinhibitorinhibit

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