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Cat. No.: HY-N17929

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Doliroside A

Doliroside A is an Aβ42-binding agent with an IC₅₀ of 26.57 μM for Aβ42. Doliroside A binds to Aβ42 nuclei and oligomers to form stable complexes, suppresses Aβ42 fibrillation, and redirects Aβ42 into off-pathway, amorphous oligomers. Doliroside A can be used for the research of alzheimer’s disease (ad).

For research use only. We do not sell to patients.

CAS No.: 93078-67-2
Formula: C₃₇H₅₈O₁₁
Molecular Weight:678.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Doliroside A Chemical Structure

CAS No.: 93078-67-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Doliroside A (2.5-250 μM; up to 40 h) potently inhibits Aβ42 fibrillogenesis with an IC₅₀ of 26.57 μM, showing concentration-dependent reduction of ThT fluorescence associated with Aβ42 fibril formation^[1].
Doliroside A (125 μM; up to 30 h) suppresses the increase of β-sheet content in Aβ42 and inhibits the formation of insoluble β-sheet-rich fibrils during Aβ42 aggregation^[1].
Doliroside A (125 μM; 24 h) alters Aβ42 aggregation morphology, redirecting the formation of fibrillar aggregates into amorphous oligomers^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 93078-67-2
Molecular Weight 678.85
Formula C₃₇H₅₈O₁₁
SMILES

C[C@]12[C@@](CC=C3[C@]2(CC[C@@]4([C@@]3([H])CC(C)(CC4)C)C(O)=O)C)([H])[C@@]5([C@@]([C@@](C)([C@H]([C@H](C5)O)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)C(OC)=O)([H])CC1)C
Structure Classification
- Terpenoids
- Tetracyclic Triterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li D, et al. Doliroside A from Dolichos falcata Klein suppressing amyloid β-protein 42 fibrillogenesis: An insight at molecular level. PLoS One. 2017;12(10):e0186590. Published 2017 Oct 30. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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