DOTA-SMIC-1014 

DOTA-SMIC-1014 is a DOTA chelator-conjugated precursor of the c-Met-targeting peptide SMIC-1014 (HY-P11863). DOTA-SMIC-1014 binds to the extracellular domain of c-Met (K_d = 42.83 nM). After radiolabeling to [⁶⁸Ga]Ga-SMIC-1014, DOTA-SMIC-1014 acts as a positron emission tomography (PET) probe that achieves specific tumor uptake in xenografts and functions as a diagnostic probe targeting c-Met. SMIC-1014 can be used in research related to colon cancer, hepatocellular carcinoma, and prostate cancer^[1].

[⁶⁸Ga]Ga-SMIC-1014 binds to c-Met on HCT-116 human colon cancer cells, with a K_d value of 42.83 nM and a B_max value of 188291 CPM, indicating high binding affinity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DOTA-SMIC-1014 (800-fold molar excess; i.v.; single coinjection with [⁶⁸Ga]Ga-SMIC-1014) significantly blocks specific c-Met-targeted tumor uptake of [⁶⁸Ga]Ga-SMIC-1014 in HCT-116 xenografts mice, reducing uptake by ~66% at 30 minutes post-injection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1571.69

C₆₈H₁₀₆N₂₀O₂₃

DOTA-{βAla}-d{Arg-Leu-Asp}-Gly-d{Pro-Glu}-Gly-d{Pro-Phe-Gln}-NH2

DOTA-{βAla}-d{RLD}-G-d{PE}-G-d{PFQ}-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Luo R, et al. Harnessing Insights of Hepatocyte Growth Factor Kringle 3 Domain to Develop c-Met Targeted Positron Emission Tomography Probe. Journal of medicinal chemistry. 2026 Jan 08;69(1):488-500.  [Content Brief]