DPPE-PEG2000-F3

DPPE-PEG2000-F3 is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing spatial separation between the lipid surface and the targeting ligand. 3. F3 peptide: Targeting/functional ligand-the F3 peptide is a fragment of human high-mobility group box 2 (HMGB2) that specifically binds to nucleolin, which is highly expressed on the surface of cancer cells, tumor angiogenesis, and vascular endothelial cell membranes, and enters the cell via clathrin-dependent endocytosis.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.