2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. (E/Z)-HA155

(E/Z)-HA155 is a potent autotaxin (ATX) type I inhibitor. (E/Z)-HA155 can be used for researching cancer, fibrotic diseases, inflammation, pain and angiogenesis.

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(E/Z)-HA155

(E/Z)-HA155 화학구조

CAS No. : 1229652-22-5

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of (E/Z)-HA155:

(E/Z)-HA155 Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

(E/Z)-HA155 is a potent autotaxin (ATX) type I inhibitor. (E/Z)-HA155 can be used for researching cancer, fibrotic diseases, inflammation, pain and angiogenesis[1].

IC50 & Target

Autotaxin[1]
Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
5.67 nM
Compound: 73
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine release
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine release
[PMID: 20536182]
HEK293 IC50
5.7 nM
Compound: 1, HA155
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as choline release using lysophosphatidylcholine as substrate after 4 hrs by choline release assay
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as choline release using lysophosphatidylcholine as substrate after 4 hrs by choline release assay
[PMID: 21615078]
분자량

463.29

화학식

C24H19BFNO5S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OB(O)C1=CC=C(C=C1)COC2=CC=C(C=C2)/C=C(C3=O)\SC(N3CC4=CC=C(C=C4)F)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 125 mg/mL (269.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1585 mL 10.7924 mL 21.5848 mL
5 mM 0.4317 mL 2.1585 mL 4.3170 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1585 mL 10.7924 mL 21.5848 mL 53.9619 mL
5 mM 0.4317 mL 2.1585 mL 4.3170 mL 10.7924 mL
10 mM 0.2158 mL 1.0792 mL 2.1585 mL 5.3962 mL
15 mM 0.1439 mL 0.7195 mL 1.4390 mL 3.5975 mL
20 mM 0.1079 mL 0.5396 mL 1.0792 mL 2.6981 mL
25 mM 0.0863 mL 0.4317 mL 0.8634 mL 2.1585 mL
30 mM 0.0719 mL 0.3597 mL 0.7195 mL 1.7987 mL
40 mM 0.0540 mL 0.2698 mL 0.5396 mL 1.3490 mL
50 mM 0.0432 mL 0.2158 mL 0.4317 mL 1.0792 mL
60 mM 0.0360 mL 0.1799 mL 0.3597 mL 0.8994 mL
80 mM 0.0270 mL 0.1349 mL 0.2698 mL 0.6745 mL
100 mM 0.0216 mL 0.1079 mL 0.2158 mL 0.5396 mL
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(E/Z)-HA155 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-HA1551229652-22-5Phosphodiesterase (PDE)AutotaxinCancerFibrotic diseasesInflammationPainAngiogenesisInhibitorinhibitorinhibit

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상품명:
(E/Z)-HA155
Cat. No.:
HY-116100
수량:
MCE Japan Authorized Agent:

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