2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Anti-infection
  3. HSP Bacterial
  4. EG36

EG36 is a selective E. coli DnaK inhibitor that inhibits DnaK ATPase activity at a concentration of 100 μM. EG36 directly binds to the nucleotide-binding domain (NBD) of E. coli DnaK by disrupting the DnaK-DnaJ interaction. EG36 can be used for research on bacterial infectious diseases.

For research use only. We do not sell to patients.

EG36

EG36 Chemical Structure

CAS No. : 2215779-34-1

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EG36 Related Antibodies

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Description

EG36 is a selective E. coli DnaK inhibitor that inhibits DnaK ATPase activity at a concentration of 100 μM. EG36 directly binds to the nucleotide-binding domain (NBD) of E. coli DnaK by disrupting the DnaK-DnaJ interaction. EG36 can be used for research on bacterial infectious diseases[1].

IC50 & Target[1]

HSP70

 

In Vitro

EG36 (50-200 μM) inhibits DnaJ-GrpE-stimulated ATPase activity of purified E. coli DnaK in a dose-dependent manner, with measurable inhibition at 50, 100, and 200 μM, and enhanced inhibition with increasing DnaJ concentrations[1].
EG36 directly binds to the isolated nucleotide-binding domain of E. coli DnaK and inhibits its inherent ATPase activity[1].
EG36 does not act as a general Hsp inhibitor, as it does not alter the ATPase activity or thermal stability of bacterial HtpG[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EG36 Related Antibodies
Molecular Weight

624.74

Formula

C37H41FN4O4
CAS No.
SMILES

COC1=CC=CC=C1N2CCC(CN3CCOC4=C(CC5=CC(C(N(CC3)C)=O)=CC=C5)C=C(C=C4)C6=CN=C(C=C6)F)(CC2)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EG36 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EG362215779-34-1EG 36EG-36HSPBacterialHeat shock proteinsE. coli DnaKsubstrate-binding domainbacterial HtpGDnaK-DnaJ interactionsE. coli DnaK SBDDnaJ-GrpEE. coli DnaK NBDbacterial HSP90ATPase activitynucleotide-binding domainInhibitorinhibitorinhibit

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