EGFR-IN-102
EGFR-IN-102 (compound 6) is an oral active EGFR inhibitor with the IC50 of 2 nM, and can be used for study of non-small-cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 2781912-10-3
- Formula: C37H37F2N7O2S
- Molecular Weight:681.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
1 nM
Compound: 57
|
Cytotoxicity against mouse BaF3 cells expressing EGFR L858R/T790M/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay
Cytotoxicity against mouse BaF3 cells expressing EGFR L858R/T790M/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay
|
[PMID: 36178776] |
| BaF3 | IC50 |
2 nM
Compound: 57
|
Cytotoxicity against mouse BaF3 cells harboring EGFR L858R/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay
Cytotoxicity against mouse BaF3 cells harboring EGFR L858R/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay
|
[PMID: 36178776] |
| L-363 | GI50 |
1.32 μM
Compound: 57
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Antiproliferative activity against human L-363 cells assessed as cell growth inhibition
Antiproliferative activity against human L-363 cells assessed as cell growth inhibition
|
[PMID: 36178776] |
| NCI-H292 | GI50 |
0.35 μM
Compound: 57
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Antiproliferative activity against human NCI-H292 cells assessed as cell growth inhibition
Antiproliferative activity against human NCI-H292 cells assessed as cell growth inhibition
|
[PMID: 36178776] |
| SU-DHL-6 | GI50 |
1.46 μM
Compound: 57
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Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition
Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition
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[PMID: 36178776] |
Chemical Information
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CAS No. 2781912-10-3
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Molecular Weight 681.80
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Formula C37H37F2N7O2S
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SMILES
CC1=C(C=C(C2=CN(N=C21)C(C3=C4CCC5(N4C=N3)CC5)C(NC6=NC=CS6)=O)C(F)F)C#CC7=CC=C(C=C7)CN8CCC(CC8)CO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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