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製品番号: HY-157912

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EGFR-IN-102

EGFR-IN-102 (compound 6) is an oral active EGFR inhibitor with the IC₅₀ of 2 nM, and can be used for study of non-small-cell lung cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2781912-10-3
分子式: C₃₇H₃₇F₂N₇O₂S
分子量:681.80

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

EGFR-IN-102 構造式

CAS 番号: 2781912-10-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

生物活性

製品説明

EGFR-IN-102 (compound 6) is an oral active EGFR inhibitor with the IC₅₀ of 2 nM, and can be used for study of non-small-cell lung cancer^[1].

EGFR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	1 nM Compound: 57	Cytotoxicity against mouse BaF3 cells expressing EGFR L858R/T790M/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay Cytotoxicity against mouse BaF3 cells expressing EGFR L858R/T790M/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay	[PMID: 36178776]
BaF3	IC₅₀	2 nM Compound: 57	Cytotoxicity against mouse BaF3 cells harboring EGFR L858R/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay Cytotoxicity against mouse BaF3 cells harboring EGFR L858R/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay	[PMID: 36178776]
L-363	GI₅₀	1.32 μM Compound: 57	Antiproliferative activity against human L-363 cells assessed as cell growth inhibition Antiproliferative activity against human L-363 cells assessed as cell growth inhibition	[PMID: 36178776]
NCI-H292	GI₅₀	0.35 μM Compound: 57	Antiproliferative activity against human NCI-H292 cells assessed as cell growth inhibition Antiproliferative activity against human NCI-H292 cells assessed as cell growth inhibition	[PMID: 36178776]
SU-DHL-6	GI₅₀	1.46 μM Compound: 57	Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition	[PMID: 36178776]

化学情報

CAS 番号 2781912-10-3
分子量 681.80
分子式 C₃₇H₃₇F₂N₇O₂S
SMILES

CC1=C(C=C(C2=CN(N=C21)C(C3=C4CCC5(N4C=N3)CC5)C(NC6=NC=CS6)=O)C(F)F)C#CC7=CC=C(C=C7)CN8CCC(CC8)CO
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ram W. Sabnis, et al. Combination of Allosteric and Orthosteric EGFR Inhibitors for Treating Non-Small-Cell Lung Cancer. ACS Med. Chem. Lett. 2024.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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