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Cat. No.: HY-157912

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EGFR-IN-102

EGFR-IN-102 (compound 6) is an oral active EGFR inhibitor with the IC₅₀ of 2 nM, and can be used for study of non-small-cell lung cancer.

For research use only. We do not sell to patients.

CAS No.: 2781912-10-3
Formula: C₃₇H₃₇F₂N₇O₂S
Molecular Weight:681.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

EGFR-IN-102 Chemical Structure

CAS No.: 2781912-10-3

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

EGFR-IN-102 (compound 6) is an oral active EGFR inhibitor with the IC₅₀ of 2 nM, and can be used for study of non-small-cell lung cancer^[1].

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	1 nM Compound: 57	Cytotoxicity against mouse BaF3 cells expressing EGFR L858R/T790M/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay Cytotoxicity against mouse BaF3 cells expressing EGFR L858R/T790M/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay	[PMID: 36178776]
BaF3	IC₅₀	2 nM Compound: 57	Cytotoxicity against mouse BaF3 cells harboring EGFR L858R/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay Cytotoxicity against mouse BaF3 cells harboring EGFR L858R/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay	[PMID: 36178776]
L-363	GI₅₀	1.32 μM Compound: 57	Antiproliferative activity against human L-363 cells assessed as cell growth inhibition Antiproliferative activity against human L-363 cells assessed as cell growth inhibition	[PMID: 36178776]
NCI-H292	GI₅₀	0.35 μM Compound: 57	Antiproliferative activity against human NCI-H292 cells assessed as cell growth inhibition Antiproliferative activity against human NCI-H292 cells assessed as cell growth inhibition	[PMID: 36178776]
SU-DHL-6	GI₅₀	1.46 μM Compound: 57	Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition	[PMID: 36178776]

Chemical Information

CAS No. 2781912-10-3
Molecular Weight 681.80
Formula C₃₇H₃₇F₂N₇O₂S
SMILES

CC1=C(C=C(C2=CN(N=C21)C(C3=C4CCC5(N4C=N3)CC5)C(NC6=NC=CS6)=O)C(F)F)C#CC7=CC=C(C=C7)CN8CCC(CC8)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ram W. Sabnis, et al. Combination of Allosteric and Orthosteric EGFR Inhibitors for Treating Non-Small-Cell Lung Cancer. ACS Med. Chem. Lett. 2024.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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