EGFR-IN-103
EGFR-IN-103 (compound 1) is a potent EGFR inhibitor with an IC50 of 6 nM for pEGFR.
For research use only. We do not sell to patients.
- CAS No.: 2568506-66-9
- Formula: C28H24Cl2FN7O2S
- Molecular Weight:612.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
12 nM
Compound: 51
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Cytotoxicity against mouse BaF3 cells harboring EGFR L858R/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay
Cytotoxicity against mouse BaF3 cells harboring EGFR L858R/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay
|
[PMID: 36178776] |
| BaF3 | IC50 |
13 nM
Compound: 51
|
Cytotoxicity against mouse BaF3 cells expressing EGFR L858R/T790M/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay
Cytotoxicity against mouse BaF3 cells expressing EGFR L858R/T790M/C797S mutant assessed as reduction in cell viability measured after 72 hrs by cell titre glo luminescence assay
|
[PMID: 36178776] |
Chemical Information
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CAS No. 2568506-66-9
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Molecular Weight 612.51
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Formula C28H24Cl2FN7O2S
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SMILES
O=C(NC1=NC=CS1)C(N2N=C3C(C(Cl)=CC(C4=CC=C(N5CCOCC5)C=C4)=C3Cl)=C2)C6=C7N(C[C@@H](C7)F)C=N6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)