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Cat. No.: HY-162788

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EGFR-IN-121

EGFR-IN-121 (compound 15) is a EGFR and VEGFR-2 dual inhibitor with IC₅₀s of 84 and 3.5 nM, respectively.

For research use only. We do not sell to patients.

CAS No.: 418799-16-3
Formula: C₂₃H₂₆N₂O₅
Molecular Weight:410.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

EGFR-IN-121 Chemical Structure

CAS No.: 418799-16-3

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Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity

Description

EGFR-IN-121 (compound 15) is a EGFR and VEGFR-2 dual inhibitor with IC₅₀s of 84 and 3.5 nM, respectively^[1].

All EGFR Isoforms :

Chemical Information

CAS No. 418799-16-3
Molecular Weight 410.46
Formula C₂₃H₂₆N₂O₅
SMILES

O=C(C1=C(C)NC(NC1C2=CC=C(OCC3=CC=CC=C3)C(OC)=C2)=O)OC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Al-Wahaibi L H, et al. Design and Synthesis of New Dihydropyrimidine Derivatives with a Cytotoxic Effect as Dual EGFR/VEGFR-2 Inhibitors[J]. ACS Omega, 2024.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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