EGFR-IN-127
EGFR-IN-127 is an ATP-competitive EGFR inhibitor with IC50s of 136.3 nM and 161. 2 nM for EGFRdel19 and EGFRdel19/T790M/C797S, respectively. EGFR-IN-127 has the potential for the study of non-small-cell lung cancer (NSCLC).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C24H24FN7O6
- 분자량:525.49
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
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EGFRex19del 136.3 nM (IC50) |
EGFR19del/TM/CS 161.2 nM (IC50) |
EGFR-IN-127 (compound b) inhibits the lung cancer cell proliferation of A549, PC-9del19, PC-9del19/T790M/C797S, and H1975 cells,with IC50 values of 0.9464 μM, 1.1262 μM, 0.4963 μM, and 1.4142 μM, respectively[1].
EGFR-IN-127 (100 nM-1 μM; 48 h) shows a noticeable inhibition of cell migration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-9del19/T790M/C797S cells.
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Concentration:100 nM and 1 μM
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Incubation Time:48 h
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Result:Revealed a noticeable inhibition of cell migration.
Chemical Information
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분자량 525.49
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화학식 C24H24FN7O6
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SMILES
O=C(O)CN(CCN(CC(O)=O)C1)CC(NC2=CC3=C(N=CN=C3NC4=CC(F)=CC=C4)C=C2NC1=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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