EGFR-IN-127
EGFR-IN-127 is an ATP-competitive EGFR inhibitor with IC50s of 136.3 nM and 161. 2 nM for EGFRdel19 and EGFRdel19/T790M/C797S, respectively. EGFR-IN-127 has the potential for the study of non-small-cell lung cancer (NSCLC).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C24H24FN7O6
- Molecular Weight:525.49
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
EGFRex19del 136.3 nM (IC50) |
EGFR19del/TM/CS 161.2 nM (IC50) |
In Vitro
EGFR-IN-127 (compound b) inhibits the lung cancer cell proliferation of A549, PC-9del19, PC-9del19/T790M/C797S, and H1975 cells,with IC50 values of 0.9464 μM, 1.1262 μM, 0.4963 μM, and 1.4142 μM, respectively[1].
EGFR-IN-127 (100 nM-1 μM; 48 h) shows a noticeable inhibition of cell migration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-9del19/T790M/C797S cells.
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Concentration:100 nM and 1 μM
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Incubation Time:48 h
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Result:Revealed a noticeable inhibition of cell migration.
Chemical Information
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Molecular Weight 525.49
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Formel C24H24FN7O6
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SMILES
O=C(O)CN(CCN(CC(O)=O)C1)CC(NC2=CC3=C(N=CN=C3NC4=CC(F)=CC=C4)C=C2NC1=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
EGFR-IN-127 Related Classifications
HY-168112 Related Classifications
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