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Cat. No.: HY-168173

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EGFR-IN-130

EGFR-IN-130 (compound 14b) is an EGFR inhibitor and apoptosis inducer. EGFR-IN-130 triggers death of HeLa cancer cells via apoptosis induction..

For research use only. We do not sell to patients.

Formula: C₂₇H₂₅N₃O₆S
Molecular Weight:519.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

EGFR-IN-130 Chemical Structure

Size

Price

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Quantity

Sample (0.1mg)

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(In Japan)

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity

Description

EGFR-IN-130 (compound 14b) is an EGFR inhibitor and apoptosis inducer. EGFR-IN-130 triggers death of HeLa cancer cells via apoptosis induction.^[1].

All EGFR Isoforms :

Chemical Information

Molecular Weight 519.57
Formula C₂₇H₂₅N₃O₆S
SMILES

OC1=C(CN(C2=CC(C(OC)=O)=C(O)C=C2)C3=NC(/C(S3)=C/C4=CC=C(N(C)C)C=C4)=O)C=C(O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Othman SA, et al. Combining lavendustin C and 5-arylidenethiazolin-4-one-based pharmacophores toward multitarget anticancer hybrids. Bioorg Chem. 2024 Dec;153:107884. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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