EGFR-IN-133
EGFR-IN-133 (Compound 24) is an inhibitor for EGFR, that inhibits the EGFR wildtype, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S mutans with IC50 of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. EGFR-IN-133 exhibits good pharmacokinetics characteristics with high oral exposure.
For research use only. We do not sell to patients.
- CAS No.: 2809982-26-9
- Formula: C27H29F2N7O3
- Molecular Weight:537.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
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EGFR (WT) 0.1 nM (IC50) |
Chemical Information
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CAS No. 2809982-26-9
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Molecular Weight 537.56
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Formula C27H29F2N7O3
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SMILES
FC1=C2N3/C(NC2=CC(N[C@@H]4CCOC4)=C1)=N/C(C5=CC(F)=NC(C6=C(N(N=C6)C)OCCC[C@H](C3)C)=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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