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Cat. No.: HY-169428

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EGFR-IN-138

EGFR-IN-138 (compound 19) is a potent EGFR inhibitor，with IC₅₀s of 37，2.6 and 1.9 nM for Wild-type，L858R and T790M EGFR，respectively.

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Formule: C₄₂H₃₇N₇O₅
Masse moléculaire:719.79

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

EGFR-IN-138 Chemical Structure

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique

Description

EGFR-IN-138 (compound 19) is a potent EGFR inhibitor，with IC₅₀s of 37，2.6 and 1.9 nM for Wild-type，L858R and T790M EGFR，respectively^[1].

Voir tous les produits spécifiques à Isoform EGFR :

Chemical Information

Masse moléculaire 719.79
Formule C₄₂H₃₇N₇O₅
SMILES

CCC1=NC(C2=CC(NC(C3=C(C(O)=CC=C3)CN4C(C5=C(C4)C=CC=C5)=O)=O)=CC=C2)=C(N1)C6=CC=NC(NC7=C(C=CC(NC(C=C)=O)=C7)OC)=C6
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wittlinger F, et, al. Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent "Type V" Kinase Inhibitors. J Med Chem. 2024 Dec 12;67(23):21438-21469. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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EGFR-IN-138

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Description

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

EGFR-IN-138 Related Classifications

HY-169428 Related Classifications

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