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Cat. No.: HY-189683

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EGFR-IN-220

EGFR-IN-220 is a mutant-selective EGFR tyrosine kinase inhibitor. EGFR-IN-220 inhibits EGFR-19del/T790M/C797S-TK and EGFR-L858R/T790M/C797S-TK, with enzymatic IC₅₀ values <5 nM. EGFR-IN-220 exhibits antiproliferative activity in cell models expressing EGFR triple-mutant variants. EGFR-IN-220 can be used for research on non-small cell lung cancer.

For research use only. We do not sell to patients.

CAS No.: 2754396-62-6
Formula: C₂₈H₃₁BrN₈O₄S
Molecular Weight:655.57

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Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR-IN-220 Chemical Structure

CAS No.: 2754396-62-6

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One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Biological Activity

Description

IC₅₀ & Target

^[1]

EGFR-19del/T790M/C797S-TK

<5 nM (IC₅₀)

EGFR-L858R/T790M/C797S-TK

<5 nM (IC₅₀)

All EGFR Isoforms :

In Vitro

EGFR-IN-220 (H002) inhibits EGFR-19del/T790M/C797S-TK and EGFR-L858R/T790M/C797S-TK in enzymatic assays, with IC₅₀ values below 5 nM^[1].
EGFR-IN-220 shows antiproliferative activity in Ba/F3-EGFR-19del/T790M/C797S-TK and Ba/F3-EGFR-L858R/T790M/C797S-TK cells, with IC₅₀ ≥50 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS No. 2754396-62-6
Molecular Weight 655.57
Formula C₂₈H₃₁BrN₈O₄S
SMILES

CCC1=C(C=C(C(NC2=NC=C(C(NC3=CC=C4N=CC=NC4=C3N(S(C)(=O)=O)C)=N2)Br)=C1)OC)N5CC6(C5)COC6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kadam VM, et al. Recent advances in synthetic strategies of fourth-generation EGFR tyrosine kinase inhibitors under clinical trials for the treatment of resistant non-small cell lung cancer (NSCLC). Bioorganic chemistry. 2026 Oct 05;181:110353.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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EGFR-IN-220

All EGFR Isoforms

Biological Activity

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IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

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EGFR-IN-220 Related Classifications

HY-189683 Related Classifications

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