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Art. -Nr.: HY-150611

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EGFR-IN-70

Name: EGFR-IN-70
Brand: MedChemExpress
SKU: HY-150611
Price: 480.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

EGFR-IN-70 (compound 18j) is a potent EGFR inhibitor with IC₅₀ values of 23.6 and 307.5 nM for EGFR^LR/TM/CS and EGFR^WT, respectively. EGFR-IN-70 has anti-proliferative activity and suppresses phosphorylation of the EGFR. EGFR-IN-70 can be used for cancer research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.03%
CAS. Nr.: 2926716-96-1
Formel: C₃₁H₃₆ClN₅O₅S
Molecular Weight:626.17

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

EGFR-IN-70 Chemical Structure

CAS. Nr.: 2926716-96-1

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

HY-111415
EGFR-IN-5

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC₅₀: 23.6 nM (EGFR^LR/TM/CS) and 307.5 nM EGFR^WT)^[1]

Alle EGFR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	2.003 nM Compound: 18j	Antiproliferative activity against human A-431 cells harboring wild type EGFR assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human A-431 cells harboring wild type EGFR assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 35446588]
BaF3	IC₅₀	0.036 μM Compound: 18j	Antiproliferative activity against mouse BaF3 cells stably expressing EGFR L858R/T790M/C797S mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells stably expressing EGFR L858R/T790M/C797S mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 35446588]
BaF3	IC₅₀	0.052 nM Compound: 18j	Antiproliferative activity against mouse BaF3 cells harboring EGFR 19 del/T790M/C797S mutant assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against mouse BaF3 cells harboring EGFR 19 del/T790M/C797S mutant assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 35446588]
BaF3	IC₅₀	2.083 μM Compound: 18j	Cytotoxicity against mouse IL-3 dependent BaF3 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Cytotoxicity against mouse IL-3 dependent BaF3 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 35446588]
PC-9	IC₅₀	0.644 nM Compound: 18j	Antiproliferative activity against human osimertinib-resistant PC-9 cells harboring EGFR 19 del/T790M/C797S mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human osimertinib-resistant PC-9 cells harboring EGFR 19 del/T790M/C797S mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 35446588]

In Vitro

EGFR-IN-70 (compound 18j) (72 hours) has anti-proliferative activity and suppresses the proliferation of Ba/F3-EGFR^19del/TM/CS, PC-9-OR-EGFR^19del/TM/CS and A431- EGFR^WT cells with IC₅₀ values of 0.052, 0.644 and 2.003 μM, respectively^[1].
EGFR-IN-70 (compound 18j) (0-1000 nM; 2 hours; Ba/F3-EGFR^19del/TM/CS and PC-9-OR-EGFR^19del/TM/CS cells) can suppresse phosphorylation of the EGFR^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Ba/F3-EGFR^19del/TM/CS and PC-9-OR-EGFR^19del/TM/CS cells
Concentration:

1, 3, 10, 30, 100, 300 and 1000 nM
Incubation Time:

2 hours
Result:

Suppressed phosphorylation of the EGFR and the downstream signaling ERK level.

Chemical Information

CAS. Nr. 2926716-96-1
Appearance Solid
Molecular Weight 626.17
Formel C₃₁H₃₆ClN₅O₅S
Color Light yellow to yellow
SMILES

O=S(CC)(N1C2=CC(OCCCCCCOC3=CC(N4)=C(C)C=C3N5CCOCC5)=CC=C2C(C6=NC4=NC=C6Cl)=C1)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Cell Stem Cell

MMRN1-EGFR drives sialylglycan-Siglec immune evasion in AML leukemia stem cells. [Abstract]

2026 May 7;33(5):800-819.e9. PMID: 42030946

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (159.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5970 mL

7.9851 mL

15.9701 mL

5 mM

0.3194 mL

1.5970 mL

3.1940 mL

10 mM

0.1597 mL

0.7985 mL

1.5970 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chen H, et, al. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65(9):6840-6858. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.5970 mL	7.9851 mL	15.9701 mL	39.9253 mL
	5 mM	0.3194 mL	1.5970 mL	3.1940 mL	7.9851 mL
	10 mM	0.1597 mL	0.7985 mL	1.5970 mL	3.9925 mL
	15 mM	0.1065 mL	0.5323 mL	1.0647 mL	2.6617 mL
	20 mM	0.0799 mL	0.3993 mL	0.7985 mL	1.9963 mL
	25 mM	0.0639 mL	0.3194 mL	0.6388 mL	1.5970 mL
	30 mM	0.0532 mL	0.2662 mL	0.5323 mL	1.3308 mL
	40 mM	0.0399 mL	0.1996 mL	0.3993 mL	0.9981 mL
	50 mM	0.0319 mL	0.1597 mL	0.3194 mL	0.7985 mL
	60 mM	0.0266 mL	0.1331 mL	0.2662 mL	0.6654 mL
	80 mM	0.0200 mL	0.0998 mL	0.1996 mL	0.4991 mL
	100 mM	0.0160 mL	0.0799 mL	0.1597 mL	0.3993 mL

Bioz

Keywords

EGFR-IN-70

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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EGFR-IN-70

Publications Citing Use of MedChemExpress (MCE) EGFR-IN-70

Alle EGFR Isoform-spezifische Produkte anzeigen