EGFR-IN-70
Based on 1 publication(s) in Google Scholar
EGFR-IN-70 (compound 18j) is a potent EGFR inhibitor with IC50 values of 23.6 and 307.5 nM for EGFRLR/TM/CS and EGFRWT, respectively. EGFR-IN-70 has anti-proliferative activity and suppresses phosphorylation of the EGFR. EGFR-IN-70 can be used for cancer research.
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- Purity: 98.03%
- CAS No.: 2926716-96-1
- 화학식: C31H36ClN5O5S
- 분자량:626.17
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) EGFR-IN-70
MoreAll EGFR Isoforms
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Biological Activity
IC50: 23.6 nM (EGFRLR/TM/CS) and 307.5 nM EGFRWT)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
2.003 nM
Compound: 18j
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Antiproliferative activity against human A-431 cells harboring wild type EGFR assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human A-431 cells harboring wild type EGFR assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 35446588] |
| BaF3 | IC50 |
0.036 μM
Compound: 18j
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Antiproliferative activity against mouse BaF3 cells stably expressing EGFR L858R/T790M/C797S mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells stably expressing EGFR L858R/T790M/C797S mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 35446588] |
| BaF3 | IC50 |
0.052 nM
Compound: 18j
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Antiproliferative activity against mouse BaF3 cells harboring EGFR 19 del/T790M/C797S mutant assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against mouse BaF3 cells harboring EGFR 19 del/T790M/C797S mutant assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 35446588] |
| BaF3 | IC50 |
2.083 μM
Compound: 18j
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Cytotoxicity against mouse IL-3 dependent BaF3 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Cytotoxicity against mouse IL-3 dependent BaF3 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 35446588] |
| PC-9 | IC50 |
0.644 nM
Compound: 18j
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Antiproliferative activity against human osimertinib-resistant PC-9 cells harboring EGFR 19 del/T790M/C797S mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human osimertinib-resistant PC-9 cells harboring EGFR 19 del/T790M/C797S mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 35446588] |
EGFR-IN-70 (compound 18j) (72 hours) has anti-proliferative activity and suppresses the proliferation of Ba/F3-EGFR19del/TM/CS, PC-9-OR-EGFR19del/TM/CS and A431- EGFRWT cells with IC50 values of 0.052, 0.644 and 2.003 μM, respectively[1].
EGFR-IN-70 (compound 18j) (0-1000 nM; 2 hours; Ba/F3-EGFR19del/TM/CS and PC-9-OR-EGFR19del/TM/CS cells) can suppresse phosphorylation of the EGFR[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Ba/F3-EGFR19del/TM/CS and PC-9-OR-EGFR19del/TM/CS cells
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Concentration:1, 3, 10, 30, 100, 300 and 1000 nM
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Incubation Time:2 hours
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Result:Suppressed phosphorylation of the EGFR and the downstream signaling ERK level.
Chemical Information
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CAS No. 2926716-96-1
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Appearance Solid
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분자량 626.17
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화학식 C31H36ClN5O5S
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Color Light yellow to yellow
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SMILES
O=S(CC)(N1C2=CC(OCCCCCCOC3=CC(N4)=C(C)C=C3N5CCOCC5)=CC=C2C(C6=NC4=NC=C6Cl)=C1)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Stem Cell
2026 May 7;33(5):800-819.e9. PMID: 42030946
용액&용해도
DMSO : 100 mg/mL (159.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (283 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5970 mL | 7.9851 mL | 15.9701 mL | 39.9253 mL |
| 5 mM | 0.3194 mL | 1.5970 mL | 3.1940 mL | 7.9851 mL | |
| 10 mM | 0.1597 mL | 0.7985 mL | 1.5970 mL | 3.9925 mL | |
| 15 mM | 0.1065 mL | 0.5323 mL | 1.0647 mL | 2.6617 mL | |
| 20 mM | 0.0799 mL | 0.3993 mL | 0.7985 mL | 1.9963 mL | |
| 25 mM | 0.0639 mL | 0.3194 mL | 0.6388 mL | 1.5970 mL | |
| 30 mM | 0.0532 mL | 0.2662 mL | 0.5323 mL | 1.3308 mL | |
| 40 mM | 0.0399 mL | 0.1996 mL | 0.3993 mL | 0.9981 mL | |
| 50 mM | 0.0319 mL | 0.1597 mL | 0.3194 mL | 0.7985 mL | |
| 60 mM | 0.0266 mL | 0.1331 mL | 0.2662 mL | 0.6654 mL | |
| 80 mM | 0.0200 mL | 0.0998 mL | 0.1996 mL | 0.4991 mL | |
| 100 mM | 0.0160 mL | 0.0799 mL | 0.1597 mL | 0.3993 mL |
EGFR-IN-70 Related Classifications
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