EGFR-IN-75
EGFR-IN-75 is an EGFRWT and EGFRT790M inhibitor with IC50 values of 0.28 μM and 5.02 μM, respectively. EGFR-IN-75 shows anticancer and antioxidant activity.
For research use only. We do not sell to patients.
- Formula: C10H6N6S2
- Molecular Weight:274.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
EGFRWT 0.28 μM (IC50) |
EGFRT790M 5.02 μM (IC50) |
In Vitro
EGFR-IN-75 (compound 2) shows cytotoxicity against MCF-7 and A549 cell lines with IC50 values of 4.92 μM and 4.69 μM, respectively[1].
EGFR-IN-75 (compound 2) also has the best antioxidant property, decreasing the radical scavenging activity by 78%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 274.32
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Formula C10H6N6S2
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SMILES
NC1=NC=NC2=C1SC3=C2C4=C(C(N)=NC=N4)S3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-75 Related Classifications
HY-152144 Related Classifications
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